Monochromatic ocular wave aberrations in young monkeys

Ramkumar Ramamirtham, Chea Su Kee, Li Fang Hung, Ying Qiao-Grider, Austin Roorda, Earl L. Smith

Research output: Journal article publicationJournal articleAcademic researchpeer-review

14 Citations (Scopus)

Abstract

High-order monochromatic aberrations could potentially influence vision-dependent refractive development in a variety of ways. As a first step in understanding the effects of wave aberration on refractive development, we characterized the maturational changes that take place in the high-order aberrations of infant rhesus monkey eyes. Specifically, we compared the monochromatic wave aberrations of infant and adolescent animals and measured the longitudinal changes in the high-order aberrations of infant monkeys during the early period when emmetropization takes place. Our main findings were that (1) adolescent monkey eyes have excellent optical quality, exhibiting total RMS errors that were slightly better than those for adult human eyes that have the same numerical aperture and (2) shortly after birth, infant rhesus monkeys exhibited relatively larger magnitudes of high-order aberrations predominately spherical aberration, coma, and trefoil, which decreased rapidly to assume adolescent values by about 200 days of age. The results demonstrate that rhesus monkey eyes are a good model for studying the contribution of individual ocular components to the eye's overall aberration structure, the mechanisms responsible for the improvements in optical quality that occur during early ocular development, and the effects of high-order aberrations on ocular growth and emmetropization.
Original languageEnglish
Pages (from-to)3616-3633
Number of pages18
JournalVision Research
Volume46
Issue number21
DOIs
Publication statusPublished - 1 Oct 2006
Externally publishedYes

Keywords

  • Emmetropization
  • Refractive error
  • Rhesus monkeys
  • Wave aberrations

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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