Molecular weight-dependent anticoagulation activity of sulfated cellulose derivatives

Zhao Mei Wang, Kai Jun Xiao, Lin Li, Jianyong Wu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

29 Citations (Scopus)

Abstract

This work is to examine the molecular weight (MW)-anticoagulation activity relationship of sulfated cellulose derivatives (cellulose sulfates, CS). The initial CS with a degree of substitution (1.59) was prepared by homogeneous sulfation of microcrystalline cellulose in an ionic liquid [C4mim]Cl. It was then hydrolyzed in a dilute acidic solution and separated into four MW fractions of 59, 23, 10 × 103g/mol and below 2.7 × 103g/mol. The anticoagulation activities based on in vitro assays of coagulation time and coagulation factors in human plasma showed a positive correlation with the MW of CS, while the activity assay of clotting time in rats exhibited a negative correlation with the MW 10-59 × 103g/mol, and the fraction with a MW <2.7 × 103g/mol exhibited a more moderate and durable activity. The results indicate that MW is a major factor on the anticoagulant properties of CS derivatives and higher MW range is favorable for in vitro, and lower MW suitable for in vivo applications.
Original languageEnglish
Pages (from-to)953-961
Number of pages9
JournalCellulose
Volume17
Issue number5
DOIs
Publication statusPublished - 12 Aug 2010

Keywords

  • Acidic degradation
  • Anticoagulation
  • Ionic liquid
  • Molecular weight
  • Sulfated cellulose derivatives

ASJC Scopus subject areas

  • Polymers and Plastics

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