Molecular neuroimaging of the serotonergic system with Positron Emission Tomography

L. R. Silberbauer, G. M. James, M. Spies, P. Michenthaler, G. S. Kranz, S. Kasper, R. Lanzenberger

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

Abstract

Positron emission tomography enables to quantify protein expression and to visualize physiological processes in vivo based on the measurement of highly specific radioligands bound to the target molecule of interest. While medications targeting the serotonergic neurotransmitter system are widely used in the treatment of psychiatric disorders, imaging of molecular changes using PET allowed for the elucidation of the contribution of this neurotransmitter system to the pathophysiology of these diseases. Here, we provide an overview of the basic measurement principles and available radioligands and demonstrate applications in basic and clinical research.

Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages175-194
Number of pages20
DOIs
Publication statusPublished - Jan 2020

Publication series

NameHandbook of Behavioral Neuroscience
Volume31
ISSN (Print)1569-7339

Keywords

  • Anxiety disorder
  • Major depressive disorder
  • Neuroimaging
  • Positron emission tomography
  • Serotonin

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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