Molecular dynamics simulation of a microvillus in a cross flow

X. Y. Chen, Yang Liu, R. M C So, J. M. Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)


One of the functions of microvilli in the microvessel endothelial glycocalyx is molecular filtering. The microvillus behaves as a mechanosensory system which may sense the fluid shear and drag forces. The permeability of small particles in microvessel is crucial for drug design and drug delivery. Therefore a better understanding of flow field around microvillus is important to simulate accurately the particle penetration in microvessel. Since the dimension of the microvilli is about ∼10 nm, the conventional Navier-Stokes equation may not be good enough to simulate the fluid flow in such microscale and nanoscale structures. Molecular dynamics (MD) simulation is a powerful method to simulate the fluid flow at the molecular level. As a first attempt, the microvillus is reduced as a two-dimensional cylinder which is in a cross flow. The detailed drag and lift together with flow field are obtained and compared with available data.
Original languageEnglish
Pages (from-to)1643-1646
Number of pages4
JournalModern Physics Letters B
Issue number28-29
Publication statusPublished - 20 Dec 2005


  • Microvillus
  • Molecular dynamics

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials
  • Statistical and Nonlinear Physics
  • Mathematical Physics


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