Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus

Ming Liu, Marcus Ho Yin Wong, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

37 Citations (Scopus)


Vibrio parahaemolyticus is a major causative agent of gastroenteritis and is the leading cause of food-borne illness in Hong Kong. Recent studies of resistance to extended-spectrum β-lactams and fluoroquinolones in V. parahaemolyticus have caused huge concern. This work reports the characterisation of a multidrug resistance conjugative plasmid in V. parahaemolyticus isolated from shrimp samples from Hong Kong. The plasmid is ca. 200 kb and carries multidrug resistance genes, including a novel plasmid-mediated quinolone resistance gene qnrVC6 surrounded by several known and novel insertion sequence (IS) elements, an extended-spectrum β-lactamase gene blaPER-1mediated by ISCR1, and a ca. 3-kb four-gene cassette (aacA3, catB2, dfrA1 and aadA1) class 1 integron. Transmission of this multidrug resistance conjugative plasmid among Vibrio spp. would compromise the effectiveness of Vibrio infection control and pose a huge threat to public health. and the International Society of Chemotherapy.
Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Issue number6
Publication statusPublished - 1 Dec 2013


  • bla PER-1
  • Multidrug resistance
  • Novel integron
  • qnrVC6
  • Vibrio parahaemolyticus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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