Abstract
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 5209-5221 |
| Number of pages | 13 |
| Journal | Marine Drugs |
| Volume | 12 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 17 Oct 2014 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water
Keywords
- Multidrug resistance (MDR)
- Ningalin B analogues
- P-glycoprotein
- P-gp modulators
- Pyrrole
ASJC Scopus subject areas
- Drug Discovery
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