Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors

Chao Yang, Iris L.K. Wong, Wen Bin Jin, Tao Jiang, Ming Cheung Chow, Sheng Biao Wan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.
Original languageEnglish
Pages (from-to)5209-5221
Number of pages13
JournalMarine Drugs
Volume12
Issue number10
DOIs
Publication statusPublished - 17 Oct 2014

Keywords

  • Multidrug resistance (MDR)
  • Ningalin B analogues
  • P-glycoprotein
  • P-gp modulators
  • Pyrrole

ASJC Scopus subject areas

  • Drug Discovery

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