Micro-perforated structures with a backing cavity is a device for providing efficient noise absorption. In a practical and industrial setting, the efficiency of Micro-Perforated Structure (MPS) may be influenced by the vibro-acoustic behavior of the surrounding systems, the shape of the micro-perforated structure as well as different kinds of excitation. In this paper, the Patch Transfer Functions (PTF) approach is proposed to model the MPS behaviour in such Complex Vibro-Acoustic Environment The PTF method is a substructuring approach which allows assembling different vibro-acoustic subsystems coupled through surfaces. The proposed PTF formulation of the MPS is capable of taking the micro-perforations and the flexibility of the structures into account and allows easy prediction of the efficiency of a MPS in a practical vibro-acoustic environment. In order to validate the present approach, PTF results are compared with experimental measurements.