Abstract
Ebola virus disease (EVD) is a rare but fatal disease of humans and other primates caused by Ebola viruses. Study shows that the 2014–2015 EVD outbreak causes more than 10,000 deaths. In this paper, we propose and analyze a deterministic model to study the transmission dynamics of EVD in Sierra Leone, Guinea, and Liberia. Our analyses show that the model has two equilibria: (1) the disease-free equilibrium (DFE) which is locally asymptotically stable when the basic reproduction number (R) is less than unity and unstable if it is greater than one, and (2) an endemic equilibrium (EE) which is globally asymptotically stable when R is greater than unity. Furthermore, the backward bifurcation occurs, a coexistence between a stale DFE and a stable EE even if the R is less than unity, which makes the disease control more strenuous and would depend on the initial size of subpopulation. By fitting to reported Ebola cases from Sierra Leone, Guinea, and Liberia in 2014–2015, our model has captured the epidemic patterns in all three countries and shed light on future Ebola control and prevention strategies.
Original language | English |
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Article number | 102 |
Pages (from-to) | 82-102 |
Number of pages | 20 |
Journal | Bulletin of Mathematical Biology |
Volume | 82 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Aug 2020 |
Keywords
- Bifurcation
- Ebola virus disease
- Mathematical modeling
- Stability analysis
ASJC Scopus subject areas
- General Neuroscience
- Immunology
- General Mathematics
- General Biochemistry,Genetics and Molecular Biology
- General Environmental Science
- Pharmacology
- General Agricultural and Biological Sciences
- Computational Theory and Mathematics