TY - JOUR
T1 - Modeling leukemia with zebrafish (Danio rerio)
T2 - Towards precision medicine
AU - Yi, Zhen Ni
AU - Chen, Xiang Ke
AU - Ma, Alvin Chun Hang
N1 - Funding Information:
The study was supported by RGC TRS[ T12-702/20-N ] and HMRF [ 06173226 ] to ACM .
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/12/15
Y1 - 2022/12/15
N2 - Leukemia is a type of blood cancer characterized by high genetic heterogeneity and fatality. While chemotherapy remains the primary form of treatment for leukemia, its effectiveness was profoundly diminished by the genetic heterogeneity and cytogenetic abnormalities of leukemic cells. Therefore, there is an unmet need to develop precision medicine for leukemia with distinct genetic backgrounds. Zebrafish (Danio rerio), a freshwater fish with exceptional feasibility in genome editing, is a powerful tool for rapid human cancer modeling. In the past decades, zebrafish have been adopted in modeling human leukemia, exploring the molecular mechanisms of underlying genetic abnormalities, and discovering novel therapeutic agents. Although many recurrent mutations of leukemia have been modeled in zebrafish for pathological study and drug discovery, its great potential in leukemia modeling was not yet fully exploited, particularly in precision medicine. In this review, we evaluated the current zebrafish models of leukemia/pre-leukemia and genetic techniques and discussed the potential of zebrafish models with novel techniques, which may contribute to the development of zebrafish as a disease model for precision medicine in treating leukemia.
AB - Leukemia is a type of blood cancer characterized by high genetic heterogeneity and fatality. While chemotherapy remains the primary form of treatment for leukemia, its effectiveness was profoundly diminished by the genetic heterogeneity and cytogenetic abnormalities of leukemic cells. Therefore, there is an unmet need to develop precision medicine for leukemia with distinct genetic backgrounds. Zebrafish (Danio rerio), a freshwater fish with exceptional feasibility in genome editing, is a powerful tool for rapid human cancer modeling. In the past decades, zebrafish have been adopted in modeling human leukemia, exploring the molecular mechanisms of underlying genetic abnormalities, and discovering novel therapeutic agents. Although many recurrent mutations of leukemia have been modeled in zebrafish for pathological study and drug discovery, its great potential in leukemia modeling was not yet fully exploited, particularly in precision medicine. In this review, we evaluated the current zebrafish models of leukemia/pre-leukemia and genetic techniques and discussed the potential of zebrafish models with novel techniques, which may contribute to the development of zebrafish as a disease model for precision medicine in treating leukemia.
KW - Disease modeling
KW - Genetic heterogeneity
KW - Genetic manipulation
KW - Leukemia
KW - Personalized medicine
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85140918462&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2022.113401
DO - 10.1016/j.yexcr.2022.113401
M3 - Journal article
C2 - 36306826
AN - SCOPUS:85140918462
SN - 0014-4827
VL - 421
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 2
M1 - 113401
ER -