Modeling cell adhesion and extravasation in microvascular system

L. L. Xiao, W. W. Yan, Y. Liu, S. Chen, B. M. Fu

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

2 Citations (Scopus)

Abstract

The blood flow behaviors in the microvessels determine the transport modes and further affect the metastasis of circulating tumor cells (CTCs). Much biochemical and biological efforts have been made on CTC metastasis; however, precise experimental measurement and accurate theoretical prediction on its mechanical mechanism are limited. To complement these, numerical modeling of a CTC extravasation from the blood circulation, including the steps of adhesion and transmigration, is discussed in this chapter. The results demonstrate that CTCs prefer to adhere at the positive curvature of curved microvessels, which is attributed to the positive wall shear stress/gradient. Then, the effects of particulate nature of blood on CTC adhesion are investigated and are found to be significant in the microvessels. Furthermore, the presence of red blood cell (RBC) aggregates is also found to promote the CTC adhesion by providing an additional wall-directed force. Finally, a single cell passing through a narrow slit, mimicking CTC transmigration, was examined under the effects of cell deformability. It showed that the cell shape and surface area increase play a more important role than the cell elasticity in cell transit across the narrow slit.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages219-234
Number of pages16
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1097
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • cell adhesion
  • Modeling and simulation
  • microcirculation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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