@inbook{8c3044dbdf514a2e9aee255a82c5dc0a,
title = "Modeling cell adhesion and extravasation in microvascular system",
abstract = "The blood flow behaviors in the microvessels determine the transport modes and further affect the metastasis of circulating tumor cells (CTCs). Much biochemical and biological efforts have been made on CTC metastasis; however, precise experimental measurement and accurate theoretical prediction on its mechanical mechanism are limited. To complement these, numerical modeling of a CTC extravasation from the blood circulation, including the steps of adhesion and transmigration, is discussed in this chapter. The results demonstrate that CTCs prefer to adhere at the positive curvature of curved microvessels, which is attributed to the positive wall shear stress/gradient. Then, the effects of particulate nature of blood on CTC adhesion are investigated and are found to be significant in the microvessels. Furthermore, the presence of red blood cell (RBC) aggregates is also found to promote the CTC adhesion by providing an additional wall-directed force. Finally, a single cell passing through a narrow slit, mimicking CTC transmigration, was examined under the effects of cell deformability. It showed that the cell shape and surface area increase play a more important role than the cell elasticity in cell transit across the narrow slit.",
keywords = "cell adhesion, Modeling and simulation, microcirculation",
author = "Xiao, {L. L.} and Yan, {W. W.} and Y. Liu and S. Chen and Fu, {B. M.}",
note = "Funding Information: Acknowledgments Supports given by HKRGC PolyU 5202/13E, PolyU G-YBG9 and G-UACM, National Nat- Fig. 4 Snapshots of the cell deformation for different relaxed shapes through the narrow slit from the front view (the upper row) and the top view (the lower row) separately. A/V is 0.667 μm−1 in (a), 0.730 μm−1 in (b, c) and (d). (b, c) and (d) represent that the seminor axis of the cell is parallel to y, x, and z axis, respectively ural Science Foundation of China (Grant No. 51276130), and NIH SC1 CA153325-01 are gratefully acknowledged. Publisher Copyright: {\textcopyright} Springer International Publishing AG, part of Springer Nature 2018. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
doi = "10.1007/978-3-319-96445-4_12",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "219--234",
booktitle = "Advances in Experimental Medicine and Biology",
address = "United States",
}