@article{c48e69e8d60f44a2ac83053887d1a254,
title = "Mind the gaps: functional networks disrupted by white matter hyperintensities are associated with greater falls risk",
abstract = "White matter hyperintensities (WMH) are associated with greater falls risk and slow gait speed. Whether these deficits are caused by the disruption of large-scale functional networks remains inconclusive. Further, physical activity moderates the association between WMHs and falls, but whether this extends to the disruption of functional networks remains unknown. One hundred and sixty-four adults (>55 years old) were included in this study. Using lesion network mapping, we identified significant correlations between the percentage of WMH-related disruption of the dorsal attention network and Physiological Profile Assessment (PPA) score (r = 0.24, p < 0.01); and between disruption of both the sensorimotor (r = 0.23, p < 0.01) and ventral attention networks (r = 0.21, p = 0.01) with foam sway. There were no significant associations with floor sway or gait speed. Physical activity moderated the association between the dorsal attention network and PPA score (p = 0.045). Thus, future research should investigate whether physical activity should be recommended in the clinical management of older adults with cerebral small vessel disease.",
keywords = "Cerebral small vessel disease, Falls risk, Functional connectivity, Physical activity, Postural sway, White matter hyperintensities",
author = "Crockett, {Rachel A.} and Hsu, {Chun Liang} and Elizabeth Dao and Roger Tam and Walid Alkeridy and Eng, {Janice J.} and Handy, {Todd C.} and Teresa Liu-Ambrose",
note = "Funding Information: Funding was provided by an Alzheimer Society Research Program Grant ( F13-05246 ), the Canadian Institutes of Health Research ( MOB-93373 ), and the Heart and Stroke Foundation of Canada ( G-15-0009019 ) to TL-A. RAC is a recipient of the UBC Rehabilitation Sciences Doctoral Award, CLH is a Canadian Institutes of Health Research Postdoctoral Fellow, and ED is a Michael Smith Foundation of Health Research Post-Doctoral Fellow. JJE is a Canada Research Chair (Tier I) in Neurological Rehabilitation and TL-A is a Canada Research Chair (Tier II) in Physical Activity, Mobility, and Cognitive Neuroscience. The authors extend our sincere gratitude to Dr. Michael Fox from the Laboratory for Brain Network and Imaging Modulation at Harvard Medical School for providing his expertise and support with lesion network mapping. Funding Information: Funding was provided by an Alzheimer Society Research Program Grant (F13-05246), the Canadian Institutes of Health Research (MOB-93373), and the Heart and Stroke Foundation of Canada (G-15-0009019) to TL-A. RAC is a recipient of the UBC Rehabilitation Sciences Doctoral Award, CLH is a Canadian Institutes of Health Research Postdoctoral Fellow, and ED is a Michael Smith Foundation of Health Research Post-Doctoral Fellow. JJE is a Canada Research Chair (Tier I) in Neurological Rehabilitation and TL-A is a Canada Research Chair (Tier II) in Physical Activity, Mobility, and Cognitive Neuroscience. The authors extend our sincere gratitude to Dr. Michael Fox from the Laboratory for Brain Network and Imaging Modulation at Harvard Medical School for providing his expertise and support with lesion network mapping. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/j.neurobiolaging.2021.09.023",
language = "English",
volume = "109",
pages = "166--175",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}