Millifluidic synthesis of cadmium sulfide nanoparticles and their application in bioimaging

Liying Hong, Tai Lok Cheung, Nanxi Rao, Qingling Ouyang, Yue Wang, Shuwen Zeng, Chengbin Yang, Dang Cuong, Peter Han Joo Chong, Liwei Liu, Wing Cheung Law, Ken Tye Yong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

18 Citations (Scopus)


In this paper, a miniature fluidic synthesis platform utilizing millimeter dimension channels for the synthesis of cadmium sulfide (CdS) quantum dots and nanocrystals is demonstrated. Traditional nanoparticle synthesis techniques involve macroscopic flasks where reaction conditions may vary at different positions inside the vessel. Therefore challenges in terms of batch reproducibility for large scale production are of great concern. Here, we show that it is possible to replicate reaction conditions so as to produce nanoparticles with similar optical characteristics across different batches using the same reaction parameters. Particle size control was established by varying the flow rate of the precursors, yielding gradually increasing nanocrystal sizes from 2.4 nm to 3.7 nm with increasing residence time. The as-synthesized CdS nanoparticles exhibited tunable photoluminescence by adjusting the molar ratio of the cadmium and sulfur precursors, giving rise to greenish-blue and orange-red emissions under ultraviolet light illumination. The particles were then studied and characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) absorbance, photoluminescence, X-ray diffraction (XRD) and selected area electron diffraction (SAED) techniques. Lastly, bioimaging of RAW264.7 mice macrophage cells using ligand exchanged CdS nanoparticles is presented.
Original languageEnglish
Pages (from-to)36819-36832
Number of pages14
JournalRSC Advances
Issue number58
Publication statusPublished - 1 Jan 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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