Microfluidic techniques for development of 3D vascularized tissue

Anwarul Hasan, Arghya Paul, Nihal E. Vrana, Xin Zhao, Adnan Memic, Yu Shik Hwang, Mehmet R. Dokmeci, Ali Khademhosseini

Research output: Journal article publicationReview articleAcademic researchpeer-review

239 Citations (Scopus)


Development of a vascularized tissue is one of the key challenges for the successful clinical application of tissue engineered constructs. Despite the significant efforts over the last few decades, establishing a gold standard to develop three dimensional (3D) vascularized tissues has still remained far from reality. Recent advances in the application of microfluidic platforms to the field of tissue engineering have greatly accelerated the progress toward the development of viable vascularized tissue constructs. Numerous techniques have emerged to induce the formation of vascular structure within tissues which can be broadly classified into two distinct categories, namely (1) prevascularization-based techniques and (2) vasculogenesis and angiogenesis-based techniques. This review presents an overview of the recent advancements in the vascularization techniques using both approaches for generating 3D vascular structure on microfluidic platforms.
Original languageEnglish
Pages (from-to)7308-7325
Number of pages18
Issue number26
Publication statusPublished - 1 Jan 2014
Externally publishedYes


  • Angiogenesis
  • Microfluidics
  • Micromolding
  • Tissue engineering
  • Vascularization
  • Vasculogenesis

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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