TY - JOUR
T1 - Microfluidic Fabrication of Bioinspired Cavity-Microfibers for 3D Scaffolds
AU - Tian, Ye
AU - Wang, Jianchun
AU - Wang, Liqiu
N1 - Funding Information:
The financial support from the Research Grants Council of Hong Kong (CRF-C1018-17G, GRF-17204718, 17237316, 17211115 and 17207914), the University of Hong Kong (URC 201511159108 and201411159074), the pilot project scheme and basic research grant (2015.4-2017.4) of Shandong Academy of Sciences, Shandong Province Natural Science Foundation (ZR2016BB15) and the Youth Science Fund of Shandong Academy of Sciences (2016QN006) is gratefully acknowledged. This work was also supported in part by the Zhejiang Provincial, Hangzhou Municipal, and Lin’an County Governments.
Funding Information:
The financial support from the Research Grants Council of Hong Kong (CRF-C1018-17G, GRF-17204718,17237316, 17211115 and17207914), the University of Hong Kong (URC 201511159108and201411159074) the pilot project scheme and basic research grant (2015.4-2017.4) of Shandong Academy of Sciences, Shandong Province Natural Science Foundation (ZR2016BB15) and the Youth Science Fund of Shandong Academy of Sciences (2016QN006) is gratefully acknowledged. This work was also supported in part by the Zhejiang Provincial, Hangzhou Municipal and Lin'an County Governments.
Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/9/5
Y1 - 2018/9/5
N2 - We present a gas-in-water microfluidic method to precisely fabricate well-controlled versatile microfibers with cavity knots (named cavity-microfiber), like tiny-cavity-microfiber, hybrid-cavity-microfiber, cavity-microfiber, and chained microfiber. The cavity-microfibers are endowed with tunable morphologies, unique surface properties, high specific surface area, assembling ability, flexibility, cytocompatibility, and hydroscopicity. We assemble cavity-microfibers as 3D scaffolds for culturing the human umbilical vein endothelial cells (HUVECs) and dehumidifying. The HUVECs on the scaffolds demonstrate good cell viability and 3D HUVECs frameworks, confirming the unique cytocompatibility of cavity-microfiber. And the cavity-microfibers and their scaffolds also demonstrate excellent dehumidifying ability and large-scale dehumidifying, respectively. Our cavity-microfiber can offer a broad range of applications in sensor, wearable electronics, dehumidifying, water collection engineering, drug delivery, biomaterials, and tissue engineering.
AB - We present a gas-in-water microfluidic method to precisely fabricate well-controlled versatile microfibers with cavity knots (named cavity-microfiber), like tiny-cavity-microfiber, hybrid-cavity-microfiber, cavity-microfiber, and chained microfiber. The cavity-microfibers are endowed with tunable morphologies, unique surface properties, high specific surface area, assembling ability, flexibility, cytocompatibility, and hydroscopicity. We assemble cavity-microfibers as 3D scaffolds for culturing the human umbilical vein endothelial cells (HUVECs) and dehumidifying. The HUVECs on the scaffolds demonstrate good cell viability and 3D HUVECs frameworks, confirming the unique cytocompatibility of cavity-microfiber. And the cavity-microfibers and their scaffolds also demonstrate excellent dehumidifying ability and large-scale dehumidifying, respectively. Our cavity-microfiber can offer a broad range of applications in sensor, wearable electronics, dehumidifying, water collection engineering, drug delivery, biomaterials, and tissue engineering.
KW - cavity-microfiber
KW - cell culture
KW - dehumidifying
KW - gas-in-water
KW - microfiber
KW - microfluidics
UR - http://www.scopus.com/inward/record.url?scp=85052322564&partnerID=8YFLogxK
U2 - 10.1021/acsami.8b09212
DO - 10.1021/acsami.8b09212
M3 - Journal article
C2 - 30113807
AN - SCOPUS:85052322564
SN - 1944-8244
VL - 10
SP - 29219
EP - 29226
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 35
ER -