Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Pei Zhao; Jianchun Wang; Chengmin Chen; Jianmei Wang; Guangxia Liu; Krishnaswamy Nandakumar; Yan Li; Liqiu Wang

doi:10.3390/mi13020200

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Pei Zhao, Jianchun Wang, Chengmin Chen, Jianmei Wang, Guangxia Liu, Krishnaswamy Nandakumar, Yan Li, Liqiu Wang

Research output: Journal article publication › Review article › Academic research › peer-review

11 Citations (Scopus)

Abstract

Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

Original language	English
Article number	200
Journal	Micromachines
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/mi13020200
Publication status	Published - Feb 2022
Externally published	Yes

Keywords

Drug carrier
Drug development
Drug toxicity screening
Micro/nanoparticles
Microfluidic technology
Organs-on-chips

ASJC Scopus subject areas

Control and Systems Engineering
Mechanical Engineering
Electrical and Electronic Engineering

More information

10.3390/mi13020200

Cite this

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title = "Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening",

abstract = "Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.",

keywords = "Drug carrier, Drug development, Drug toxicity screening, Micro/nanoparticles, Microfluidic technology, Organs-on-chips",

author = "Pei Zhao and Jianchun Wang and Chengmin Chen and Jianmei Wang and Guangxia Liu and Krishnaswamy Nandakumar and Yan Li and Liqiu Wang",

note = "Funding Information: The present study was supported by Shandong Provincial Key R&D Project (2021CXGC010515); the Double Hundred Plan of Shandong Province (WST2017001); the International S&T Cooperation Program of Shandong Academy of Sciences (2019GHPY06). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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month = feb,

doi = "10.3390/mi13020200",

language = "English",

volume = "13",

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AU - Zhao, Pei

AU - Wang, Jianchun

AU - Chen, Chengmin

AU - Wang, Jianmei

AU - Liu, Guangxia

AU - Nandakumar, Krishnaswamy

AU - Li, Yan

AU - Wang, Liqiu

N1 - Funding Information: The present study was supported by Shandong Provincial Key R&D Project (2021CXGC010515); the Double Hundred Plan of Shandong Province (WST2017001); the International S&T Cooperation Program of Shandong Academy of Sciences (2019GHPY06). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2

Y1 - 2022/2

N2 - Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

AB - Microfluidic technology has been highly useful in nanovolume sample preparation, sepa-ration, synthesis, purification, detection and assay, which are advantageous in drug development. This review highlights the recent developments and trends in microfluidic applications in two areas of drug development. First, we focus on how microfluidics has been developed as a facile tool for the fabrication of drug carriers including microparticles and nanoparticles. Second, we discuss how microfluidic chips could be used as an independent platform or integrated with other technologies in drug toxicity screening. Challenges and future perspectives of microfluidic applications in drug development have also been provided considering the present technological limitations.

KW - Drug carrier

KW - Drug development

KW - Drug toxicity screening

KW - Micro/nanoparticles

KW - Microfluidic technology

KW - Organs-on-chips

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M3 - Review article

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ER -

Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening

Abstract

Keywords

ASJC Scopus subject areas

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