Microencapsulation of Traditional Chinese Herbs-PentaHerbs extracts and potential application in healthcare textiles

Chi Leung Hui, Wen Yi Wang, Chi Wai Kan, Frency Sau Fun Ng, Elaine Wat, Vanilla Xin Zhang, Chung Lap Chan, Clara Bik San Lau, Ping Chung Leung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

31 Citations (Scopus)

Abstract

In this work, Traditional Chinese Herbs (TCH)-PentaHerbs-was successfully microencapsulated in chitosan-sodium alginate (CSA) blend matrix using emulsion-chemical cross-linking method and the final product was characterised with regard to structure, surface morphology, particle size, in vitro drug release and skin toxicity by means of Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), laser diffraction particle size analysis, high performance liquid chromatography (HPLC) and methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) release assays respectively. Results showed that the microcapsules were in spherical form with diameter mostly in the range of 3-18. μm and that the release performance of the microcapsules was influenced by pH value of phosphate buffer solution (PBS). The microcapsules had no toxic effects on cells and were successfully grafted onto the surface of cotton fabrics. These results indicated that PentaHerbs loaded CSA microcapsule may possess potential application in clinical treatment of atopic dermatitis (AD).
Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume111
DOIs
Publication statusPublished - 1 Nov 2013

Keywords

  • Atopic dermatitis
  • Healthcare textiles
  • Microencapsulation
  • PentaHerbs

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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