Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO2 process

Ai Zheng Chen, Yi Li, Foo Tim Chau, Tsui Yan Lau, Jun Yan Hu, Zheng Zhao, Kam Wah Mok

Research output: Journal article publicationJournal articleAcademic researchpeer-review

62 Citations (Scopus)


Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO2(SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and lower concentration was obtained and applied in the SEDS process. The resulting puerarin nanoparticles were then suspended in PLLA solution and microencapsulated by PLLA in a modified SEDS process, where an 'injector' was employed in the particle suspension delivery system. The puerarin nanoparticles exhibited a good spherical shape, a smooth surface and a narrow particle size distribution with a mean particle size of 188 nm. After microencapsulation the puerarin-PLLA microparticles had a mean size of 675 nm, a drug load of 23.6% and an encapsulation efficiency of 39.4%; after a burst release at the first stage, the drug was released in a sustained process. Compared with the parallel study of a co-precipitation process, this microencapsulation process is a much more promising technique to prepare a drug-polymer carrier for a drug delivery system, especially for protein drugs.
Original languageEnglish
Pages (from-to)2913-2919
Number of pages7
JournalActa Biomaterialia
Issue number8
Publication statusPublished - 1 Oct 2009


  • Biomaterials
  • Microencapsulation
  • Poly(l-lactide)
  • Puerarin
  • Supercritical CO 2

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology


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