Abstract
Puerarin nanoparticles were firstly prepared in the process of solution-enhanced dispersion by supercritical CO2(SEDS) and then successfully microencapsulated by poly(l-lactide) (PLLA) in a modified SEDS process. By adding an organic non-solvent, an initial puerarin solution with a higher degree of saturation and lower concentration was obtained and applied in the SEDS process. The resulting puerarin nanoparticles were then suspended in PLLA solution and microencapsulated by PLLA in a modified SEDS process, where an 'injector' was employed in the particle suspension delivery system. The puerarin nanoparticles exhibited a good spherical shape, a smooth surface and a narrow particle size distribution with a mean particle size of 188 nm. After microencapsulation the puerarin-PLLA microparticles had a mean size of 675 nm, a drug load of 23.6% and an encapsulation efficiency of 39.4%; after a burst release at the first stage, the drug was released in a sustained process. Compared with the parallel study of a co-precipitation process, this microencapsulation process is a much more promising technique to prepare a drug-polymer carrier for a drug delivery system, especially for protein drugs.
Original language | English |
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Pages (from-to) | 2913-2919 |
Number of pages | 7 |
Journal | Acta Biomaterialia |
Volume | 5 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Oct 2009 |
Keywords
- Biomaterials
- Microencapsulation
- Poly(l-lactide)
- Puerarin
- Supercritical CO 2
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Biotechnology
- Biochemistry
- Molecular Biology