Microbiota-microglia connections in age-related cognition decline

Rui Zhou; Shufang Qian; William C.S. Cho; Jinyun Zhou; Chentao Jin; Yan Zhong; Jing Wang; Xiaohui Zhang; Zhoujiao Xu; Mei Tian; Lawrence W.C. Chan; Hong Zhang

doi:10.1111/acel.13599

Microbiota-microglia connections in age-related cognition decline

Rui Zhou, Shufang Qian, William C.S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W.C. Chan, Hong Zhang

Research output: Journal article publication › Review article › Academic research › peer-review

12 Citations (Scopus)

Abstract

Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).

Original language	English
Article number	e13599
Journal	Aging Cell
Volume	21
Issue number	5
DOIs	https://doi.org/10.1111/acel.13599
Publication status	Published - May 2022

Keywords

cognitive aging
gut microbiota
microglia
neuroinflammation

ASJC Scopus subject areas

Ageing
Cell Biology

More information

10.1111/acel.13599

Cite this

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title = "Microbiota-microglia connections in age-related cognition decline",

abstract = "Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).",

keywords = "cognitive aging, gut microbiota, microglia, neuroinflammation",

author = "Rui Zhou and Shufang Qian and Cho, {William C.S.} and Jinyun Zhou and Chentao Jin and Yan Zhong and Jing Wang and Xiaohui Zhang and Zhoujiao Xu and Mei Tian and Chan, {Lawrence W.C.} and Hong Zhang",

note = "Funding Information: We thank the support of National Natural Science Foundation of China (81725009, 21788102 and 82030049) and National Key R&D Program of China (2021YFE0108300). Publisher Copyright: {\textcopyright} 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",

year = "2022",

month = may,

doi = "10.1111/acel.13599",

language = "English",

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journal = "Aging Cell",

issn = "1474-9718",

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T1 - Microbiota-microglia connections in age-related cognition decline

AU - Zhou, Rui

AU - Qian, Shufang

AU - Cho, William C.S.

AU - Zhou, Jinyun

AU - Jin, Chentao

AU - Zhong, Yan

AU - Wang, Jing

AU - Zhang, Xiaohui

AU - Xu, Zhoujiao

AU - Tian, Mei

AU - Chan, Lawrence W.C.

AU - Zhang, Hong

N1 - Funding Information: We thank the support of National Natural Science Foundation of China (81725009, 21788102 and 82030049) and National Key R&D Program of China (2021YFE0108300). Publisher Copyright: © 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

PY - 2022/5

Y1 - 2022/5

N2 - Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).

AB - Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).

KW - cognitive aging

KW - gut microbiota

KW - microglia

KW - neuroinflammation

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U2 - 10.1111/acel.13599

DO - 10.1111/acel.13599

M3 - Review article

C2 - 35349746

AN - SCOPUS:85127256007

SN - 1474-9718

VL - 21

JO - Aging Cell

JF - Aging Cell

IS - 5

M1 - e13599

ER -

Microbiota-microglia connections in age-related cognition decline

Abstract

Keywords

ASJC Scopus subject areas

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