Microbiocidal characterization of a novel povidone-iodine based rigid contact lens disinfecting solution

P. Cho, S. Reyes, M. V. Boost

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)


This study investigated the efficacy of a novel povidone-iodine based disinfection solution for rigid gas permeable (RGP) lenses compared to three other currently available multipurpose and hydrogen peroxide solutions. Bactericidal and fungicidal activities were assessed using ISO 14729 reference methods, whilst amoebicidal properties were evaluated using an automated viability counter. All solutions were also assessed for long term storage stability over a 3-month period. The FDA guidelines were adequately achieved by all solutions tested and 3-month storage did not affect their activity against bacterial and fungal agents. Activity against Acanthamoeba castellani trophozoites reached 1-log reduction for the povidone-iodine solution and approached this level for the remaining solutions. Activity against cysts was somewhat reduced and ranged from 78 to 86% reduction in viability. A povidone-iodine based solution, which may offer advantages as resistance to this agent has not been demonstrated and it lacks toxicity, provided equivalent antimicrobial activity to other RGP solutions.

Original languageEnglish
Pages (from-to)542-546
Number of pages5
JournalContact Lens and Anterior Eye
Issue number6
Early online dateAug 2018
Publication statusPublished - Dec 2018


  • Acanthamoeba
  • Contact lens
  • Disinfection
  • Povidone-iodine
  • RGP

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry


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