Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research

Qingjun Liu; Jinjiang Yu; Hui Yu; Lidan Xiao; Ping Wang; Mo Yang

doi:10.1007/978-3-540-79039-6-78

Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research

Qingjun Liu, Jinjiang Yu, Hui Yu, Lidan Xiao, Ping Wang, Mo Yang

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

5 Citations (Scopus)

Abstract

In this study, cell biosensor chip with microelectrode arrays was used to monitor the culture behaviour of mammalian cancer cells and evaluate the chemosensitivity of anti-cancer drugs using electrochemical impedance spectroscopy. The electrode arrays were fabricated by semiconductor technology with diameter from 50 μm to 10 μm of each electrode. The human oesophageal cancer cell lines (KYSE 30) were cultured on the surface of the electrode with the help of fibronectin. Morphology changes of cells adhesion, spreading, and proliferation can be detected by impedimetric analysis in a real time and non-invasive way. Anti-caner drug of cisplatin was added to cells for potential drug screening applications. The experimental results show that drug's chemosensitivity effects can be detected by this cell based biosensor.

Original language	English
Title of host publication	7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008
Pages	309-312
Number of pages	4
Volume	19 IFMBE
DOIs	https://doi.org/10.1007/978-3-540-79039-6-78
Publication status	Published - 1 Dec 2008
Event	7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008 - Beijing, China Duration: 22 Apr 2008 → 25 Apr 2008

Conference

Conference	7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008
Country/Territory	China
City	Beijing
Period	22/04/08 → 25/04/08

Keywords

Anticancer drugs
Cancer
Cell-based biosensor
Chemosensitivity
Impedance spectroscopy
Micro-electrode arrays

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-540-79039-6-78

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title = "Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research",

abstract = "In this study, cell biosensor chip with microelectrode arrays was used to monitor the culture behaviour of mammalian cancer cells and evaluate the chemosensitivity of anti-cancer drugs using electrochemical impedance spectroscopy. The electrode arrays were fabricated by semiconductor technology with diameter from 50 μm to 10 μm of each electrode. The human oesophageal cancer cell lines (KYSE 30) were cultured on the surface of the electrode with the help of fibronectin. Morphology changes of cells adhesion, spreading, and proliferation can be detected by impedimetric analysis in a real time and non-invasive way. Anti-caner drug of cisplatin was added to cells for potential drug screening applications. The experimental results show that drug's chemosensitivity effects can be detected by this cell based biosensor.",

keywords = "Anticancer drugs, Cancer, Cell-based biosensor, Chemosensitivity, Impedance spectroscopy, Micro-electrode arrays",

author = "Qingjun Liu and Jinjiang Yu and Hui Yu and Lidan Xiao and Ping Wang and Mo Yang",

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volume = "19 IFMBE",

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booktitle = "7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008",

note = "7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008 ; Conference date: 22-04-2008 Through 25-04-2008",

}

Liu, Q, Yu, J, Yu, H, Xiao, L, Wang, P & Yang, M 2008, Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research. in 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008. vol. 19 IFMBE, pp. 309-312, 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008, Beijing, China, 22/04/08. https://doi.org/10.1007/978-3-540-79039-6-78

Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research. / Liu, Qingjun; Yu, Jinjiang; Yu, Hui et al.
7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008. Vol. 19 IFMBE 2008. p. 309-312.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research

AU - Liu, Qingjun

AU - Yu, Jinjiang

AU - Yu, Hui

AU - Xiao, Lidan

AU - Wang, Ping

AU - Yang, Mo

PY - 2008/12/1

Y1 - 2008/12/1

N2 - In this study, cell biosensor chip with microelectrode arrays was used to monitor the culture behaviour of mammalian cancer cells and evaluate the chemosensitivity of anti-cancer drugs using electrochemical impedance spectroscopy. The electrode arrays were fabricated by semiconductor technology with diameter from 50 μm to 10 μm of each electrode. The human oesophageal cancer cell lines (KYSE 30) were cultured on the surface of the electrode with the help of fibronectin. Morphology changes of cells adhesion, spreading, and proliferation can be detected by impedimetric analysis in a real time and non-invasive way. Anti-caner drug of cisplatin was added to cells for potential drug screening applications. The experimental results show that drug's chemosensitivity effects can be detected by this cell based biosensor.

AB - In this study, cell biosensor chip with microelectrode arrays was used to monitor the culture behaviour of mammalian cancer cells and evaluate the chemosensitivity of anti-cancer drugs using electrochemical impedance spectroscopy. The electrode arrays were fabricated by semiconductor technology with diameter from 50 μm to 10 μm of each electrode. The human oesophageal cancer cell lines (KYSE 30) were cultured on the surface of the electrode with the help of fibronectin. Morphology changes of cells adhesion, spreading, and proliferation can be detected by impedimetric analysis in a real time and non-invasive way. Anti-caner drug of cisplatin was added to cells for potential drug screening applications. The experimental results show that drug's chemosensitivity effects can be detected by this cell based biosensor.

KW - Anticancer drugs

KW - Cancer

KW - Cell-based biosensor

KW - Chemosensitivity

KW - Impedance spectroscopy

KW - Micro-electrode arrays

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M3 - Conference article published in proceeding or book

SN - 9783540790389

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SP - 309

EP - 312

BT - 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008

T2 - 7th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2008

Y2 - 22 April 2008 through 25 April 2008

ER -

Micro-electrode cell-based biosensor using electrochemical impedance spectroscopy for cancer research

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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