Micro chip with nanostructured membranes for cell morphology monitoring

Jinjiang Yu, Chen Chao, Ching Hsiang Cheng, Qingjun Liu, Lidan Xiao, Mo Yang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

We present a novel nanostructured micro cell chip with impedance spectroscopy for monitoring cell morphology change non-invasively, in real time and independent of any fluorescent or radioactive probes. The key strategy is to integrate the nanoporous alumina membrane with silicon based microfluidic devices for the impedance monitoring. In this configuration, the impedance of even single cell can be measured at the low frequency range but not be affected by the electrode polarization. The KYSE30 human oesophageal cancer cells have been successfully cultured on nanoporous alumina membrane. Initial electrochemical experiments with lipid layers have been done to testify the functionality of this device. Further experiments for cancer cells will be explored in near future.
Original languageEnglish
Title of host publication2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings
Pages304-307
Number of pages4
DOIs
Publication statusPublished - 1 Dec 2007
Event2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, Hong Kong
Duration: 2 Aug 20075 Aug 2007

Conference

Conference2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
Country/TerritoryHong Kong
CityHong Kong
Period2/08/075/08/07

Keywords

  • Impedance spectroscopy
  • KYSE30 human oesophageal cancer cells
  • Microcell chip
  • Nanoporous alumina menbrane

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

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