Micro chip with nanostructured membranes for cell morphology monitoring

Jinjiang Yu; Chen Chao; Ching Hsiang Cheng; Qingjun Liu; Lidan Xiao; Mo Yang

doi:10.1109/NANO.2007.4601195

Micro chip with nanostructured membranes for cell morphology monitoring

Jinjiang Yu, Chen Chao, Ching Hsiang Cheng, Qingjun Liu, Lidan Xiao, Mo Yang

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

Abstract

We present a novel nanostructured micro cell chip with impedance spectroscopy for monitoring cell morphology change non-invasively, in real time and independent of any fluorescent or radioactive probes. The key strategy is to integrate the nanoporous alumina membrane with silicon based microfluidic devices for the impedance monitoring. In this configuration, the impedance of even single cell can be measured at the low frequency range but not be affected by the electrode polarization. The KYSE30 human oesophageal cancer cells have been successfully cultured on nanoporous alumina membrane. Initial electrochemical experiments with lipid layers have been done to testify the functionality of this device. Further experiments for cancer cells will be explored in near future.

Original language	English
Title of host publication	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings
Pages	304-307
Number of pages	4
DOIs	https://doi.org/10.1109/NANO.2007.4601195
Publication status	Published - 1 Dec 2007
Event	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, Hong Kong Duration: 2 Aug 2007 → 5 Aug 2007

Conference

Conference	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
Country/Territory	Hong Kong
City	Hong Kong
Period	2/08/07 → 5/08/07

Keywords

Impedance spectroscopy
KYSE30 human oesophageal cancer cells
Microcell chip
Nanoporous alumina menbrane

ASJC Scopus subject areas

Electrical and Electronic Engineering
Atomic and Molecular Physics, and Optics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1109/NANO.2007.4601195

Cite this

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title = "Micro chip with nanostructured membranes for cell morphology monitoring",

abstract = "We present a novel nanostructured micro cell chip with impedance spectroscopy for monitoring cell morphology change non-invasively, in real time and independent of any fluorescent or radioactive probes. The key strategy is to integrate the nanoporous alumina membrane with silicon based microfluidic devices for the impedance monitoring. In this configuration, the impedance of even single cell can be measured at the low frequency range but not be affected by the electrode polarization. The KYSE30 human oesophageal cancer cells have been successfully cultured on nanoporous alumina membrane. Initial electrochemical experiments with lipid layers have been done to testify the functionality of this device. Further experiments for cancer cells will be explored in near future.",

keywords = "Impedance spectroscopy, KYSE30 human oesophageal cancer cells, Microcell chip, Nanoporous alumina menbrane",

author = "Jinjiang Yu and Chen Chao and Cheng, {Ching Hsiang} and Qingjun Liu and Lidan Xiao and Mo Yang",

year = "2007",

month = dec,

day = "1",

doi = "10.1109/NANO.2007.4601195",

language = "English",

isbn = "1424406080",

pages = "304--307",

booktitle = "2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings",

note = "2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 ; Conference date: 02-08-2007 Through 05-08-2007",

}

Yu, J, Chao, C, Cheng, CH, Liu, Q, Xiao, L & Yang, M 2007, Micro chip with nanostructured membranes for cell morphology monitoring. in 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings., 4601195, pp. 304-307, 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Hong Kong, Hong Kong, 2/08/07. https://doi.org/10.1109/NANO.2007.4601195

Micro chip with nanostructured membranes for cell morphology monitoring. / Yu, Jinjiang; Chao, Chen; Cheng, Ching Hsiang et al.
2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings. 2007. p. 304-307 4601195.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - Micro chip with nanostructured membranes for cell morphology monitoring

AU - Yu, Jinjiang

AU - Chao, Chen

AU - Cheng, Ching Hsiang

AU - Liu, Qingjun

AU - Xiao, Lidan

AU - Yang, Mo

PY - 2007/12/1

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N2 - We present a novel nanostructured micro cell chip with impedance spectroscopy for monitoring cell morphology change non-invasively, in real time and independent of any fluorescent or radioactive probes. The key strategy is to integrate the nanoporous alumina membrane with silicon based microfluidic devices for the impedance monitoring. In this configuration, the impedance of even single cell can be measured at the low frequency range but not be affected by the electrode polarization. The KYSE30 human oesophageal cancer cells have been successfully cultured on nanoporous alumina membrane. Initial electrochemical experiments with lipid layers have been done to testify the functionality of this device. Further experiments for cancer cells will be explored in near future.

AB - We present a novel nanostructured micro cell chip with impedance spectroscopy for monitoring cell morphology change non-invasively, in real time and independent of any fluorescent or radioactive probes. The key strategy is to integrate the nanoporous alumina membrane with silicon based microfluidic devices for the impedance monitoring. In this configuration, the impedance of even single cell can be measured at the low frequency range but not be affected by the electrode polarization. The KYSE30 human oesophageal cancer cells have been successfully cultured on nanoporous alumina membrane. Initial electrochemical experiments with lipid layers have been done to testify the functionality of this device. Further experiments for cancer cells will be explored in near future.

KW - Impedance spectroscopy

KW - KYSE30 human oesophageal cancer cells

KW - Microcell chip

KW - Nanoporous alumina menbrane

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SN - 9781424406081

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BT - 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Proceedings

T2 - 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007

Y2 - 2 August 2007 through 5 August 2007

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Micro chip with nanostructured membranes for cell morphology monitoring

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

More information

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