TY - JOUR
T1 - Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy
AU - Huang, Junfeng
AU - Xu, Zhourui
AU - jiang, Yihang
AU - Law, Wing cheung
AU - Dong, Biqin
AU - Zeng, Xierong
AU - Ma, Mingze
AU - Xu, Gaixia
AU - Zou, Jizhao
AU - Yang, Chengbin
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (31871442, 81801859), Natural Science Foundation of Guangdong Province (2019A1515012163, 2020A1515011018, 2021A1515012159), Guangdong Medical Science and Technology Research Funding(A2019359), the Research Grants Council of the Hong Kong Special Administrative Region, China (PolyU 15200518 and 15208720), Shenzhen Basic Research Program (JCYJ20190808141611189, JCYJ20180305125254860), Start-up Grant from Shenzhen University (2019136), and University Stable Support Research Funding of Shenzhen (20200813153346001).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.
AB - Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.
KW - Biocompatible
KW - Drug delivery
KW - Gold nanorod
KW - Metal organic framework
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85110645207&partnerID=8YFLogxK
U2 - 10.1186/s12951-021-00961-x
DO - 10.1186/s12951-021-00961-x
M3 - Journal article
C2 - 34281545
AN - SCOPUS:85110645207
SN - 1477-3155
VL - 19
JO - Journal of Nanobiotechnology
JF - Journal of Nanobiotechnology
IS - 1
M1 - 219
ER -