@article{830afc15a7554b36a7dc29c440fbec71,
title = "Metal-free, Phosphoric Acid-catalyzed Regioselective 1,6-Hydroarylation of para-Quinone Methides with Indoles in Water",
abstract = "An efficient, cheap and green protocol for the highly regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with indoles at the C-3 position has been established by phosphoric acid catalysis in water under transition-metal-free reaction conditions. A wide range of indole derivatives and para-quinone methides (p-QMs) are compatible for the reaction, affording the corresponding 1,6-hydroarylation products with good to excellent yields. The possible mechanism of the reaction has been explored through step-by-step control experiments. The protocol is convenient for practical applications, leading to a safe, green and feasible way for the formation of C-3 diarylmethyl functionalized indole derivatives.",
keywords = "1,6-hydroarylation, br{\o}nsted-acid catalysis, green media, indoles, para-quinone methides",
author = "Biquan Xiong and Lulu Si and Yu Liu and Weifeng Xu and Tao Jiang and Fan Cao and Tang, {Ke Wen} and Wong, {Wai Yeung}",
note = "Funding Information: This work was supported by National Natural Science Foundation of China (21606080, 21908050), Natural Science Foundation of Hunan Province (2019JJ50203), Scientific Research Fund of Hunan Provincial Education Department (19A197), Innovation research group project of Natural Science Foundation of Hunan Province (No. 2020JJ1004) and National College Students Innovation and Entrepreneurship Training Program (202110543028). W.‐Y.W. thanks the CAS‐Croucher Funding Scheme for Joint Laboratories, ITC Guangdong‐Hong Kong Technology Cooperation Funding Scheme (TCFS) (GHP/038/19GD), Hong Kong Polytechnic University (1‐ZE1C) and the Endowed Professorship in Energy from Miss Clarea Au (847S) for the financial support. Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = mar,
day = "4",
doi = "10.1002/asia.202200042",
language = "English",
volume = "17",
journal = "Chemistry - An Asian Journal",
issn = "1861-4728",
publisher = "John Wiley and Sons Ltd",
number = "9",
}