Meta-analysis of neurocognitive rehabilitation for cognitive dysfunction among pediatric cancer survivors

Fang He, Haiying Huang, Liyan Ye, Xiulan Wen (Corresponding Author), Andy S.K. Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Cancer and its treatment significantly affect the cognitive functioning of pediatric cancer survivors. This meta-analysis aimed to examine the effects of neurocognitive rehabilitation interventions on the cognitive functioning and intellectual performance of pediatric cancer survivors. Four databases were searched until December 15, 2021. RevMan 5.4 was used to analyze the effects of neurocognitive rehabilitation interventions on the cognitive functioning of pediatric cancer survivors. Ten eligible randomized controlled trials were initially identified, and nine of these were included in the meta-analysis. For the working memory outcome, the pooled effect results favored study interventions and had statistical significance at postintervention assessment (Z = 2.24, P = 0.03). For the attention outcome, there were significant statistical differences at postintervention and 3/6-month follow-up assessment (Z = 2.72, P = 0.007 and Z = 10.45, P < 0.001, respectively). For the executive functioning outcome, there were significant statistical differences at postintervention and 3/6-month follow-up assessment (Z = 2.90, P = 0.004 and Z = 14.75, P < 0.001, respectively). For the academic/intellectual performance secondary outcome, the pooled overall effects of study interventions on the academic/intellectual outcome were positive at postintervention and follow-up assessment (Ps < 0.001). No studies reported any adverse events related to neurocognitive and educational interventions. This meta-analysis found that neurocognitive rehabilitation interventions improve the working memory, attention, and executive functioning of pediatric cancer survivors at postintervention and short-term follow-up. Neurocognitive rehabilitation also has positive effects on the academic/intellectual performance of this study population during a vulnerable period in their development.

Original languageEnglish
Pages (from-to)2058-2065
Number of pages8
JournalJournal of Cancer Research and Therapeutics
Volume18
Issue number7
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Cognitive functioning
  • meta-analysis
  • neurocognitive rehabilitation
  • pediatric cancer survivors

ASJC Scopus subject areas

  • General Medicine

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