Abstract
Original language | English |
---|---|
Article number | 11008 |
Journal | Nature Communications |
Volume | 7 |
DOIs | |
Publication status | Published - 29 Mar 2016 |
ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. / Fan, Qiao; Verhoeven, Virginie J.M.; Wojciechowski, Robert; Barathi, Veluchamy A.; Hysi, Pirro G.; Guggenheim, Jeremy A.; Hohn, René; Vitart, Veronique; Khawaja, Anthony P.; Yamashiro, Kenji; Hosseini, S. Mohsen; Lehtimaki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cécile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W.; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E.; Williams, Katie M.; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F.; Joshi, Peter K.; McMahon, George; St Pourcain, Beate; Evans, David M.; Simpson, Claire L.; Schwantes-An, Tae Hwi; Igo, Robert P.; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Céline; Blettner, Maria; Raitakari, Olli; Kahonen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S.; Gieger, Christian; Portas, Laura; Van Leeuwen, Elisabeth M.; Amin, Najaf; Uitterlinden, André G.; Rivadeneira, Fernando; Hofman, Albert; Vingerling, Johannes R.; Wang, Ya Xing; Wang, Xu; Tai-Hui Boh, Eileen; Ikram, M. Kamran; Sabanayagam, Charumathi; Gupta, Preeti; Tan, Vincent; Zhou, Lei; Ho, Candice E.H.; Lim, Wan'E; Beuerman, Roger W.; Siantar, Rosalynn; Yip, Shea Ping.
In: Nature Communications, Vol. 7, 11008, 29.03.2016.Research output: Journal article publication › Journal article › Academic research › peer-review
TY - JOUR
T1 - Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
AU - Fan, Qiao
AU - Verhoeven, Virginie J.M.
AU - Wojciechowski, Robert
AU - Barathi, Veluchamy A.
AU - Hysi, Pirro G.
AU - Guggenheim, Jeremy A.
AU - Hohn, René
AU - Vitart, Veronique
AU - Khawaja, Anthony P.
AU - Yamashiro, Kenji
AU - Hosseini, S. Mohsen
AU - Lehtimaki, Terho
AU - Lu, Yi
AU - Haller, Toomas
AU - Xie, Jing
AU - Delcourt, Cécile
AU - Pirastu, Mario
AU - Wedenoja, Juho
AU - Gharahkhani, Puya
AU - Venturini, Cristina
AU - Miyake, Masahiro
AU - Hewitt, Alex W.
AU - Guo, Xiaobo
AU - Mazur, Johanna
AU - Huffman, Jenifer E.
AU - Williams, Katie M.
AU - Polasek, Ozren
AU - Campbell, Harry
AU - Rudan, Igor
AU - Vatavuk, Zoran
AU - Wilson, James F.
AU - Joshi, Peter K.
AU - McMahon, George
AU - St Pourcain, Beate
AU - Evans, David M.
AU - Simpson, Claire L.
AU - Schwantes-An, Tae Hwi
AU - Igo, Robert P.
AU - Mirshahi, Alireza
AU - Cougnard-Gregoire, Audrey
AU - Bellenguez, Céline
AU - Blettner, Maria
AU - Raitakari, Olli
AU - Kahonen, Mika
AU - Seppala, Ilkka
AU - Zeller, Tanja
AU - Meitinger, Thomas
AU - Ried, Janina S.
AU - Gieger, Christian
AU - Portas, Laura
AU - Van Leeuwen, Elisabeth M.
AU - Amin, Najaf
AU - Uitterlinden, André G.
AU - Rivadeneira, Fernando
AU - Hofman, Albert
AU - Vingerling, Johannes R.
AU - Wang, Ya Xing
AU - Wang, Xu
AU - Tai-Hui Boh, Eileen
AU - Ikram, M. Kamran
AU - Sabanayagam, Charumathi
AU - Gupta, Preeti
AU - Tan, Vincent
AU - Zhou, Lei
AU - Ho, Candice E.H.
AU - Lim, Wan'E
AU - Beuerman, Roger W.
AU - Siantar, Rosalynn
AU - Yip, Shea Ping
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
AB - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
UR - http://www.scopus.com/inward/record.url?scp=84962655499&partnerID=8YFLogxK
U2 - 10.1038/ncomms11008
DO - 10.1038/ncomms11008
M3 - Journal article
C2 - 27020472
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 11008
ER -