Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Qiao Fan; Virginie J.M. Verhoeven; Robert Wojciechowski; Veluchamy A. Barathi; Pirro G. Hysi; Jeremy A. Guggenheim; René Hohn; Veronique Vitart; Anthony P. Khawaja; Kenji Yamashiro; S. Mohsen Hosseini; Terho Lehtimaki; Yi Lu; Toomas Haller; Jing Xie; Cécile Delcourt; Mario Pirastu; Juho Wedenoja; Puya Gharahkhani; Cristina Venturini; Masahiro Miyake; Alex W. Hewitt; Xiaobo Guo; Johanna Mazur; Jenifer E. Huffman; Katie M. Williams; Ozren Polasek; Harry Campbell; Igor Rudan; Zoran Vatavuk; James F. Wilson; Peter K. Joshi; George McMahon; Beate St Pourcain; David M. Evans; Claire L. Simpson; Tae Hwi Schwantes-An; Robert P. Igo; Alireza Mirshahi; Audrey Cougnard-Gregoire; Céline Bellenguez; Maria Blettner; Olli Raitakari; Mika Kahonen; Ilkka Seppala; Tanja Zeller; Thomas Meitinger; Janina S. Ried; Christian Gieger; Laura Portas; Elisabeth M. Van Leeuwen; Najaf Amin; André G. Uitterlinden; Fernando Rivadeneira; Albert Hofman; Johannes R. Vingerling; Ya Xing Wang; Xu Wang; Eileen Tai-Hui Boh; M. Kamran Ikram; Charumathi Sabanayagam; Preeti Gupta; Vincent Tan; Lei Zhou; Candice E.H. Ho; Wan'E Lim; Roger W. Beuerman; Rosalynn Siantar; Shea Ping Yip

doi:10.1038/ncomms11008

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Qiao Fan, Virginie J.M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Hohn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S. Mohsen Hosseini, Terho Lehtimaki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina VenturiniMasahiro Miyake, Alex W. Hewitt, Xiaobo Guo, Johanna Mazur, Jenifer E. Huffman, Katie M. Williams, Ozren Polasek, Harry Campbell, Igor Rudan, Zoran Vatavuk, James F. Wilson, Peter K. Joshi, George McMahon, Beate St Pourcain, David M. Evans, Claire L. Simpson, Tae Hwi Schwantes-An, Robert P. Igo, Alireza Mirshahi, Audrey Cougnard-Gregoire, Céline Bellenguez, Maria Blettner, Olli Raitakari, Mika Kahonen, Ilkka Seppala, Tanja Zeller, Thomas Meitinger, Janina S. Ried, Christian Gieger, Laura Portas, Elisabeth M. Van Leeuwen, Najaf Amin, André G. Uitterlinden, Fernando Rivadeneira, Albert Hofman, Johannes R. Vingerling, Ya Xing Wang, Xu Wang, Eileen Tai-Hui Boh, M. Kamran Ikram, Charumathi Sabanayagam, Preeti Gupta, Vincent Tan, Lei Zhou, Candice E.H. Ho, Wan'E Lim, Roger W. Beuerman, Rosalynn Siantar, Shea Ping Yip

Department of Health Technology and Informatics

Research output: Journal article publication › Journal article › Academic research › peer-review

76 Citations (Scopus)

Abstract

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Original language	English
Article number	11008
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms11008
Publication status	Published - 29 Mar 2016

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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10.1038/ncomms11008

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Fan, Q., Verhoeven, V. J. M., Wojciechowski, R., Barathi, V. A., Hysi, P. G., Guggenheim, J. A., Hohn, R., Vitart, V., Khawaja, A. P., Yamashiro, K., Hosseini, S. M., Lehtimaki, T., Lu, Y., Haller, T., Xie, J., Delcourt, C., Pirastu, M., Wedenoja, J., Gharahkhani, P., ... Yip, S. P. (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications, 7, [11008]. https://doi.org/10.1038/ncomms11008

Fan, Qiao ; Verhoeven, Virginie J.M. ; Wojciechowski, Robert ; Barathi, Veluchamy A. ; Hysi, Pirro G. ; Guggenheim, Jeremy A. ; Hohn, René ; Vitart, Veronique ; Khawaja, Anthony P. ; Yamashiro, Kenji ; Hosseini, S. Mohsen ; Lehtimaki, Terho ; Lu, Yi ; Haller, Toomas ; Xie, Jing ; Delcourt, Cécile ; Pirastu, Mario ; Wedenoja, Juho ; Gharahkhani, Puya ; Venturini, Cristina ; Miyake, Masahiro ; Hewitt, Alex W. ; Guo, Xiaobo ; Mazur, Johanna ; Huffman, Jenifer E. ; Williams, Katie M. ; Polasek, Ozren ; Campbell, Harry ; Rudan, Igor ; Vatavuk, Zoran ; Wilson, James F. ; Joshi, Peter K. ; McMahon, George ; St Pourcain, Beate ; Evans, David M. ; Simpson, Claire L. ; Schwantes-An, Tae Hwi ; Igo, Robert P. ; Mirshahi, Alireza ; Cougnard-Gregoire, Audrey ; Bellenguez, Céline ; Blettner, Maria ; Raitakari, Olli ; Kahonen, Mika ; Seppala, Ilkka ; Zeller, Tanja ; Meitinger, Thomas ; Ried, Janina S. ; Gieger, Christian ; Portas, Laura ; Van Leeuwen, Elisabeth M. ; Amin, Najaf ; Uitterlinden, André G. ; Rivadeneira, Fernando ; Hofman, Albert ; Vingerling, Johannes R. ; Wang, Ya Xing ; Wang, Xu ; Tai-Hui Boh, Eileen ; Ikram, M. Kamran ; Sabanayagam, Charumathi ; Gupta, Preeti ; Tan, Vincent ; Zhou, Lei ; Ho, Candice E.H. ; Lim, Wan'E ; Beuerman, Roger W. ; Siantar, Rosalynn ; Yip, Shea Ping. / Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. In: Nature Communications. 2016 ; Vol. 7.

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title = "Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error",

abstract = "Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.",

author = "Qiao Fan and Verhoeven, {Virginie J.M.} and Robert Wojciechowski and Barathi, {Veluchamy A.} and Hysi, {Pirro G.} and Guggenheim, {Jeremy A.} and Ren{\'e} Hohn and Veronique Vitart and Khawaja, {Anthony P.} and Kenji Yamashiro and Hosseini, {S. Mohsen} and Terho Lehtimaki and Yi Lu and Toomas Haller and Jing Xie and C{\'e}cile Delcourt and Mario Pirastu and Juho Wedenoja and Puya Gharahkhani and Cristina Venturini and Masahiro Miyake and Hewitt, {Alex W.} and Xiaobo Guo and Johanna Mazur and Huffman, {Jenifer E.} and Williams, {Katie M.} and Ozren Polasek and Harry Campbell and Igor Rudan and Zoran Vatavuk and Wilson, {James F.} and Joshi, {Peter K.} and George McMahon and {St Pourcain}, Beate and Evans, {David M.} and Simpson, {Claire L.} and Schwantes-An, {Tae Hwi} and Igo, {Robert P.} and Alireza Mirshahi and Audrey Cougnard-Gregoire and C{\'e}line Bellenguez and Maria Blettner and Olli Raitakari and Mika Kahonen and Ilkka Seppala and Tanja Zeller and Thomas Meitinger and Ried, {Janina S.} and Christian Gieger and Laura Portas and {Van Leeuwen}, {Elisabeth M.} and Najaf Amin and Uitterlinden, {Andr{\'e} G.} and Fernando Rivadeneira and Albert Hofman and Vingerling, {Johannes R.} and Wang, {Ya Xing} and Xu Wang and {Tai-Hui Boh}, Eileen and Ikram, {M. Kamran} and Charumathi Sabanayagam and Preeti Gupta and Vincent Tan and Lei Zhou and Ho, {Candice E.H.} and Wan'E Lim and Beuerman, {Roger W.} and Rosalynn Siantar and Yip, {Shea Ping}",

year = "2016",

month = mar,

day = "29",

doi = "10.1038/ncomms11008",

language = "English",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Fan, Q, Verhoeven, VJM, Wojciechowski, R, Barathi, VA, Hysi, PG, Guggenheim, JA, Hohn, R, Vitart, V, Khawaja, AP, Yamashiro, K, Hosseini, SM, Lehtimaki, T, Lu, Y, Haller, T, Xie, J, Delcourt, C, Pirastu, M, Wedenoja, J, Gharahkhani, P, Venturini, C, Miyake, M, Hewitt, AW, Guo, X, Mazur, J, Huffman, JE, Williams, KM, Polasek, O, Campbell, H, Rudan, I, Vatavuk, Z, Wilson, JF, Joshi, PK, McMahon, G, St Pourcain, B, Evans, DM, Simpson, CL, Schwantes-An, TH, Igo, RP, Mirshahi, A, Cougnard-Gregoire, A, Bellenguez, C, Blettner, M, Raitakari, O, Kahonen, M, Seppala, I, Zeller, T, Meitinger, T, Ried, JS, Gieger, C, Portas, L, Van Leeuwen, EM, Amin, N, Uitterlinden, AG, Rivadeneira, F, Hofman, A, Vingerling, JR, Wang, YX, Wang, X, Tai-Hui Boh, E, Ikram, MK, Sabanayagam, C, Gupta, P, Tan, V, Zhou, L, Ho, CEH, Lim, WE, Beuerman, RW, Siantar, R & Yip, SP 2016, 'Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error', Nature Communications, vol. 7, 11008. https://doi.org/10.1038/ncomms11008

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. / Fan, Qiao; Verhoeven, Virginie J.M.; Wojciechowski, Robert; Barathi, Veluchamy A.; Hysi, Pirro G.; Guggenheim, Jeremy A.; Hohn, René; Vitart, Veronique; Khawaja, Anthony P.; Yamashiro, Kenji; Hosseini, S. Mohsen; Lehtimaki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cécile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W.; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E.; Williams, Katie M.; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F.; Joshi, Peter K.; McMahon, George; St Pourcain, Beate; Evans, David M.; Simpson, Claire L.; Schwantes-An, Tae Hwi; Igo, Robert P.; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Céline; Blettner, Maria; Raitakari, Olli; Kahonen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S.; Gieger, Christian; Portas, Laura; Van Leeuwen, Elisabeth M.; Amin, Najaf; Uitterlinden, André G.; Rivadeneira, Fernando; Hofman, Albert; Vingerling, Johannes R.; Wang, Ya Xing; Wang, Xu; Tai-Hui Boh, Eileen; Ikram, M. Kamran; Sabanayagam, Charumathi; Gupta, Preeti; Tan, Vincent; Zhou, Lei; Ho, Candice E.H.; Lim, Wan'E; Beuerman, Roger W.; Siantar, Rosalynn; Yip, Shea Ping.

In: Nature Communications, Vol. 7, 11008, 29.03.2016.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

AU - Fan, Qiao

AU - Verhoeven, Virginie J.M.

AU - Wojciechowski, Robert

AU - Barathi, Veluchamy A.

AU - Hysi, Pirro G.

AU - Guggenheim, Jeremy A.

AU - Hohn, René

AU - Vitart, Veronique

AU - Khawaja, Anthony P.

AU - Yamashiro, Kenji

AU - Hosseini, S. Mohsen

AU - Lehtimaki, Terho

AU - Lu, Yi

AU - Haller, Toomas

AU - Xie, Jing

AU - Delcourt, Cécile

AU - Pirastu, Mario

AU - Wedenoja, Juho

AU - Gharahkhani, Puya

AU - Venturini, Cristina

AU - Miyake, Masahiro

AU - Hewitt, Alex W.

AU - Guo, Xiaobo

AU - Mazur, Johanna

AU - Huffman, Jenifer E.

AU - Williams, Katie M.

AU - Polasek, Ozren

AU - Campbell, Harry

AU - Rudan, Igor

AU - Vatavuk, Zoran

AU - Wilson, James F.

AU - Joshi, Peter K.

AU - McMahon, George

AU - St Pourcain, Beate

AU - Evans, David M.

AU - Simpson, Claire L.

AU - Schwantes-An, Tae Hwi

AU - Igo, Robert P.

AU - Mirshahi, Alireza

AU - Cougnard-Gregoire, Audrey

AU - Bellenguez, Céline

AU - Blettner, Maria

AU - Raitakari, Olli

AU - Kahonen, Mika

AU - Seppala, Ilkka

AU - Zeller, Tanja

AU - Meitinger, Thomas

AU - Ried, Janina S.

AU - Gieger, Christian

AU - Portas, Laura

AU - Van Leeuwen, Elisabeth M.

AU - Amin, Najaf

AU - Uitterlinden, André G.

AU - Rivadeneira, Fernando

AU - Hofman, Albert

AU - Vingerling, Johannes R.

AU - Wang, Ya Xing

AU - Wang, Xu

AU - Tai-Hui Boh, Eileen

AU - Ikram, M. Kamran

AU - Sabanayagam, Charumathi

AU - Gupta, Preeti

AU - Tan, Vincent

AU - Zhou, Lei

AU - Ho, Candice E.H.

AU - Lim, Wan'E

AU - Beuerman, Roger W.

AU - Siantar, Rosalynn

AU - Yip, Shea Ping

PY - 2016/3/29

Y1 - 2016/3/29

N2 - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

AB - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

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U2 - 10.1038/ncomms11008

DO - 10.1038/ncomms11008

M3 - Journal article

C2 - 27020472

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11008

ER -

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

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