TY - JOUR
T1 - Mechanistic study of synergistic antimicrobial effects between poly (3-hydroxybutyrate) oligomer and polyethylene glycol
AU - Zhang, Ziheng
AU - Li, Jun
AU - Ma, Linlin
AU - Yang, Xingxing
AU - Fei, Bin
AU - Leung, Polly H.M.
AU - Tao, Xiaoming
N1 - Funding Information:
Funding: This work was supported by the Innovation and Technology Commission of SAR Government of Hong Kong (Grant No. ITP/039/16TP). References Conflicts of Interest: The authors declare no conflict of interest
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Extended from our previous finding that poly (3-hydroxybutyrate) (PHB) oligomer is an effective antimicrobial agent against gram-positive bacteria, gram-negative bacteria, fungi and multi-drug resistant bacteria, this work investigates the effect of polyethylene glycol (PEG) on the antimicrobial effect of PHB oligomer. To investigate and explain this promoting phenomenon, three hypothetic mechanisms were proposed, that is, generation of new antimicrobial components, degradation of PHB macromolecules and dissolution/dispersion of PHB oligomer by PEG. With a series of systematic experiments and characterizations of high-performance liquid chromatography–mass spectrometry (HPLC-MS), it was deducted that PEG promotes the antimicrobial effect of PHB oligomer synergistically through dissolution/dispersion, owing to its amphipathy, which improves the hydrophilicity of PHB oligomer.
AB - Extended from our previous finding that poly (3-hydroxybutyrate) (PHB) oligomer is an effective antimicrobial agent against gram-positive bacteria, gram-negative bacteria, fungi and multi-drug resistant bacteria, this work investigates the effect of polyethylene glycol (PEG) on the antimicrobial effect of PHB oligomer. To investigate and explain this promoting phenomenon, three hypothetic mechanisms were proposed, that is, generation of new antimicrobial components, degradation of PHB macromolecules and dissolution/dispersion of PHB oligomer by PEG. With a series of systematic experiments and characterizations of high-performance liquid chromatography–mass spectrometry (HPLC-MS), it was deducted that PEG promotes the antimicrobial effect of PHB oligomer synergistically through dissolution/dispersion, owing to its amphipathy, which improves the hydrophilicity of PHB oligomer.
KW - Antimicrobial agent
KW - Oligomer
KW - Poly (3-hydroxybutyric acid)
KW - Polyethylene glycol
KW - Synergistic antimicrobial effect
UR - http://www.scopus.com/inward/record.url?scp=85096575440&partnerID=8YFLogxK
U2 - 10.3390/polym12112735
DO - 10.3390/polym12112735
M3 - Journal article
AN - SCOPUS:85096575440
SN - 2073-4360
VL - 12
SP - 1
EP - 12
JO - Polymers
JF - Polymers
IS - 11
M1 - 2735
ER -