Mechanism of anticancer effects of antimicrobial peptides

Xuan Liu, Yi Li, Zhi Li, Xiqian Lan, Hang Mei Polly Leung, Jiashen Li, Mo Yang, Frank Ko, Ling Qin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)

Abstract

Antimicrobial Peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contribute to the potential mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective targeting properties make AMPs promising candidates for alternative approach to solve the problems from anticancer drug resistance.
Original languageEnglish
Pages (from-to)25-36
Number of pages12
JournalJournal of Fiber Bioengineering and Informatics
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Anticancer activity
  • Anticancer drug resistance
  • Antimicrobial peptides
  • Electrostatic attraction
  • Hydrophobic interaction

ASJC Scopus subject areas

  • Computer Science(all)
  • Materials Science(all)

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