Mechanism of anticancer effects of antimicrobial peptides

Xuan Liu, Yi Li, Zhi Li, Xi Qian Lan, Hang Mei Polly Leung, Jia Shen Li, Mo Yang, Ko Frank, Ling Qin

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Antimicrobial peptides (AMPs) were first known as a group of innate immune products that mainly targets on the invading pathogens among multiple species. The essential mechanisms of action of AMPs toward microbial cells have been reported as electrostatic attraction and hydrophobic interaction between AMPs (cationic AMPs) and microbial cell membranes. These effects also contributed to the potential mechanism of anticancer activities of AMPs as well. The membrane difference between cancer cells and normal cells are believed to play significant roles in AMPs orienting process. Membrane selective targeting properties made AMPs promising candidates for alternative approach to solve the problems from anticancer drug resistance.
Original languageEnglish
Title of host publicationTextile Bioengineering and Informatics Symposium Proceedings 2014 - 7th Textile Bioengineering and Informatics Symposium, TBIS 2014, in conjunction with the 5th Asian Protective Clothing Conference, APCC 2014
PublisherBinary Information Press
Pages243-251
Number of pages9
Publication statusPublished - 1 Jan 2014
Event7th Textile Bioengineering and Informatics Symposium, TBIS 2014, in conjunction with the 5th Asian Protective Clothing Conference, APCC 2014 - The Hong Kong Polytechnic University, Hong Kong, Hong Kong
Duration: 6 Aug 20148 Aug 2014

Conference

Conference7th Textile Bioengineering and Informatics Symposium, TBIS 2014, in conjunction with the 5th Asian Protective Clothing Conference, APCC 2014
Country/TerritoryHong Kong
CityHong Kong
Period6/08/148/08/14

Keywords

  • Anticancer activity
  • Anticancer drug resistance
  • Antimicrobial peptides
  • Electrostatic attraction
  • Hydrophobic interaction

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials

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