Measuring Retinal Thickness and Visual Acuity in Eyes with Different Types of Astigmatism in a Cohort of Hong Kong Chinese Adults

Research output: Journal article publicationJournal articleAcademic researchpeer-review


PURPOSE. The purpose of this study was to investigate optical coherence tomography
(OCT)-measured retinal thickness (RT) and best-corrected distance visual acuity (BCDVA)
in eyes with different types of astigmatism.
METHODS. This is a case-control study of 101 participants stratified into With-The-Rule
(WTR; n = 41), Against-The-Rule (ATR; n = 25), and control (n = 35) groups by noncycloplegic
subjective refraction. Inclusion criteria were ages between 18 and 45 years,
spherical-equivalent (SE) refraction ≥−10.00 diopters (D), negative cylindrical power
(CYL) ≤−0.75 D with axes of 0 to 30 degrees/150 to 180 degrees for WTR and 60 to 120
degrees for ATR, or CYL ≥−0.25 D for controls. Participants suffering from ocular diseases
related to retinal defects, having a history of ocular surgery, with BCDVA >0.10 LogMAR,
or poor OCT imaging quality were excluded. Fovea-centered scans were performed using
spectral-domain OCT (SD-OCT), and RT automatically measured by the inbuilt software.
Only right eyes were analyzed. Groups were matched for age, gender, SE, axial length,
and corneal curvature.
RESULTS. One-way ANOVA showed a significant difference in both BCDVA (P = 0.039) and
macular RT (P = 0.028) among the three groups. Bonferroni’s post hoc test revealed statistically
significant between-group differences in BCDVA (WTR vs. controls, P = 0.041), as
well as in RT at inner-nasal (WTR vs. ATR, P = 0.034) and outer-temporal subfields (WTR
vs. controls, P = 0.042). BCDVA was positively associated with macular RT (r = 0.206, P
= 0.041) after adjusting for age, gender, and axial length.
CONCLUSIONS. Greater RT and poorer BCDVA were found in eyes with WTR astigmatism.
Our findings suggest that the effect of astigmatism on retinal thickness and BCDVA may
vary depending on not only magnitude, but also axis of astigmatism.
Original languageEnglish
Article number2
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Issue number1
Publication statusPublished - 3 Jan 2023


  • astigmatism
  • retinal thickness (RT)
  • visual acuity
  • optical coherence tomography (OCT)

ASJC Scopus subject areas

  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Ophthalmology


Dive into the research topics of 'Measuring Retinal Thickness and Visual Acuity in Eyes with Different Types of Astigmatism in a Cohort of Hong Kong Chinese Adults'. Together they form a unique fingerprint.

Cite this