Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: Implications for schizophrenia

M. Nyffeler, U. Meyer, Kay Yan Benjamin Yee, J. Feldon, I. Knuesel

Research output: Journal article publicationJournal articleAcademic researchpeer-review

99 Citations (Scopus)

Abstract

Prenatal exposures to a variety of infections have been associated with an increased incidence of schizophrenia. We have reported that a single injection of the synthetic cytokine releaser PolyI:C to pregnant mice produced offspring that exhibited multiple schizophrenia-related behavioral deficits in adulthood. Here, we characterized the effect of maternal inflammation during fetal brain development on adult limbic morphology and expression of GABAA-receptors. The PolyI:C treatment did not induce morphological abnormalities but resulted in a significant increase in GABAAreceptor subunit α2 immunoreactivity (IR) in the ventral dentate gyrus and basolateral amygdala in adult treated compared to control subjects. Correlative analyses between the a2 subunit IR in the ventral dentate gyrus and the performance in the prepulse inhibition paradigm revealed a significant correlation in controls that was however absent in the pathological condition. These results suggest that prenatal immune activation-induced disturbances of early brain development result in profound alterations in the limbic expression of GABAAreceptors that may underlie the schizophrenia-related behavioral deficits in the adult mice.
Original languageEnglish
Pages (from-to)51-62
Number of pages12
JournalNeuroscience
Volume143
Issue number1
DOIs
Publication statusPublished - 17 Nov 2006
Externally publishedYes

Keywords

  • amygdala
  • dentate gyrus
  • hippocampus
  • neurodevelopment
  • PolyI:C
  • prenatal

ASJC Scopus subject areas

  • Neuroscience(all)

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