Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study

Na Li, Lefei Han, Min Peng, Yuxia Lv, Yin Ouyang, Kui Liu, Linli Yue, Qiannan Li, Guoqiang Sun, Lin Chen, Lin Yang (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

106 Citations (Scopus)

Abstract

BACKGROUND: The ongoing epidemics of coronavirus disease 2019 (COVID-19) have caused serious concerns about its potential adverse effects on pregnancy. There are limited data on maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia. METHODS: We conducted a case-control study to compare clinical characteristics, maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia. RESULTS: During January 24 to February 29, 2020, there were sixteen pregnant women with confirmed COVID-19 pneumonia and eighteen suspected cases who were admitted to labor in the third trimester. Two had vaginal delivery and the rest took cesarean section. Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest CT images of COVID-19 pneumonia. Compared to the controls, COVID-19 pneumonia patients had lower counts of white blood cells (WBC), neutrophils, C-reactive protein (CRP), and alanine aminotransferase (ALT) on admission. Increased levels of WBC, neutrophils, eosinophils, and CRP were found in postpartum blood tests of pneumonia patients. There were three (18.8%) and three (16.7%) of the mothers with confirmed or suspected COVID-19 pneumonia had preterm delivery due to maternal complications, which were significantly higher than the control group. None experienced respiratory failure during hospital stay. COVID-19 infection was not found in the newborns and none developed severe neonatal complications. CONCLUSION: Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal delivery or caesarean section. Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission.

Original languageEnglish
Article numberciaa352
JournalClinical Infectious Diseases
Early online date30 Mar 2020
DOIs
Publication statusE-pub ahead of print - 30 Mar 2020

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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