Maternal and Neonatal Outcomes of Pregnant Women with Coronavirus Disease 2019 (COVID-19) Pneumonia

Na Li, Lefei Han, Min Peng, Yuxia Lv, Yin Ouyang, Kui Liu, Linli Yue, Qiannan Li, Guoqiang Sun, Lin Chen, Lin Yang (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

152 Citations (Scopus)

Abstract

Background: The ongoing pandemic of coronavirus disease 2019 (COVID-19) has caused serious concerns about its potential adverse effects on pregnancy. There are limited data on maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia. Methods: We conducted a case-control study to compare clinical characteristics and maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia. Results: During the period 24 January-29 February 2020, there were 16 pregnant women with confirmed COVID-19 pneumonia and 18 suspected cases who were admitted to labor in the third trimester. Two had vaginal delivery and the rest were cesarean delivery. Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest computed tomographic images of COVID-19 pneumonia. Compared to the controls, patients with COVID-19 pneumonia had lower counts of white blood cells (WBCs), neutrophils, C-reactive protein (CRP), and alanine aminotransferase on admission. Increased levels of WBCs, neutrophils, eosinophils, and CRP were found in postpartum blood tests of pneumonia patients. Three (18.8%) of the mothers with confirmed COVID-19 pneumonia and 3 (16.7%) with suspected COVID-19 pneumonia had preterm delivery due to maternal complications, which were significantly higher than in the control group. None experienced respiratory failure during their hospital stay. COVID-19 infection was not found in the newborns, and none developed severe neonatal complications. Conclusions: Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal or cesarean delivery. Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission.

Original languageEnglish
Article numberciaa352
Pages (from-to)2035-2041
Number of pages7
JournalClinical Infectious Diseases
Volume71
Issue number16
Early online date30 Mar 2020
DOIs
Publication statusPublished - 15 Oct 2020

Keywords

  • COVID-19
  • maternal outcomes
  • neonates
  • pregnancy
  • vaginal delivery

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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