Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat phenochromocytoma PC12 cells.

Xiaoli Dong, Jiaxiao ZHANG, Zhilin ZHOU, Zhennan YE, Jiahao CHEN, Jifan YUAN, Fengjun CAO, Xuanbin WANG, Wenchao LIU, Wenxuan Yu, Xiaohua Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Maslinic acid (2α, 3β-dihydroxyolean-12-en-28-oic acid, MA) was isolated from natural plants and showed anti-cancer activity in rat Pheochromocytoma PC12 cells in our previous studies. We now discover that MA disrupts the interaction between Bcl2 and autophagy scaffold protein Beclin1 in the above cell line, leading to the up-regulation of autophagy. We investigated the effect of MA on the interaction between Bcl2 and Beclin1 by biochemical and biophysical methods in combination with autophagy characterization in the above cell line. Our results suggest that MA may serve as an autophagy activator by directly blocking the Bcl2-Beclin1 interaction to release free Beclin1 required for the recruitment of autophagy positive regulators, implying MA may exert its anti-cancer activity by regulating autophagy.
Original languageEnglish
Article numberPMID: 29088805
Pages (from-to)74527-74538
JournalOncotarget
Volume8
Issue number43
DOIs
Publication statusPublished - 5 Aug 2017

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology

Fingerprint

Dive into the research topics of 'Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat phenochromocytoma PC12 cells.'. Together they form a unique fingerprint.

Cite this