Abstract
We aim to investigate the anticancer effect of a novel immunomodulator FTY720 on a rat orthotopic liver tumor model. A buffalo rat orthotopic liver tumor model was established by injection of a buffalo hepatoma cell line MH7777 into the right portal vein. FTY720 was administered by intraperitoneal injection starting at 10 days after tumor cell injection at a dosage of 5 mg/kg/day. FTY720 markedly suppressed tumor growth and inhibited tumor progression by selective induction of apoptosis of tumor cells via down-regulation of phospho-Aktser473and up-regulation of cleaved caspase-3, together with decrease of focal adhesion kinase. Moreover, the proliferation index of tumor cells was significantly reduced to 15.92±5.03% by FTY720 compared with that of 42.92±4.47% in the control group (p<0.001). In addition, we confirmed that FTY720 caused no effect on infiltrated lymphocyte in tumor tissue. We conclude that FTY720 is an effective anticancer agent for liver tumor in a rat model without affecting the immune system of the host.
Original language | English |
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Pages (from-to) | 375-380 |
Number of pages | 6 |
Journal | International Journal of Oncology |
Volume | 30 |
Issue number | 2 |
Publication status | Published - 1 Feb 2007 |
Externally published | Yes |
Keywords
- AKT signaling pathway
- Apoptosis
- Focal adhesion kinase
- FTY720
- Hepatocellular carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research