Mapping the Haem-A-QoL to the EQ-5D-5L in patients with hemophilia

Objective: This study’s objective was to develop an algorithm that mapping the Haem-A-QoL scores to EQ-5D-5L utility scores in patients with hemophilia in China. Methods: A national sample of 862 patients with hemophilia completed both the EQ-5D-5L and Haem-A-QoL instruments. Eight regression models were selected to develop the mapping algorithm, they were: the ordinary least squares, general linear regression, Tobit regression, censored least absolute deviation, mixture beta regression, adjusted limited dependent variable mixture, the two-part, and robust MM-estimator model. Root mean squared error (RMSE), mean absolute error (MAE), and R-square (R²) calculated using the tenfold cross-validation and random sample validation methods were used to assess the predictive ability of the models. Results: Based on RMSE, MAE, and R², the mixture beta regression model with selected Haem-A-QoL subscale scores as the predicted variables showed the best performance. Conclusions: Our mapping algorithm bolsters the calculation of QALYs while conducting an economic evaluation of hemophilia-related interventions when only Haem-A-QoL data are available. The external validity of the algorithm should be further assessed in the other populations.