Manganese-doped near-infrared emitting nanocrystals for in vivo biomedical imaging

Wing Cheung Law, Zhourui Xu, Ken Tye Yong, Xin Liu, Mark T. Swihart, Mukund Seshadri, Paras N. Prasad

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

� 2016 Optical Society of America. Nanoprobes with multiple imaging modality have attracted a great deal of attention due to the capability of offering complementary information from each individual component. This work presents a hybrid approach to synthesize manganese doped near infrared (NIR) emitting quantum dots. The Mn-doping process was accomplished in aqueous phase followed by a phase transfer to organic phase for ZnS coating. This bimodal nanoprobe displayed high NIR luminescence quantum yield (∼14%) and capability of magnetic resonance imaging (MRI) (1.44 mM-1s-1). The RGD-targeted nanoprobes have been exploited for in vitro cell labelling, in vivo tumor targeting and lymph node mapping. In addition, no adverse toxic effects were observed, demonstrating the high biocompatibility of this nanoprobe.
Original languageEnglish
Pages (from-to)17553-17561
Number of pages9
JournalOptics Express
Volume24
Issue number16
DOIs
Publication statusPublished - 8 Aug 2016

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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