Magnetoplasmonic nanoplatforms for enhanced bioimaging and photothermal cancer therapy

A. Kopwitthaya, T. Y. Ohulchanskyy, M. Jeon, Wing Cheung Law, X. Xue, Q. Xie, R. R. Chada, E. P. Furlani, C. Kim, P. N. Prasad

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

In this presentation we introduce a novel magnetoplasmonic nanoplatform for biomedical applications. The nanoplatform consists of a gold nanorod (GNR) and multiple Fe 3O 4 nanoparticles enclosed in a polymeric micelle-like structure. The combined magnetic and plasmonic functionality of the nanoplatform enables field-directed targeting, enhanced multimodal imaging, and therapy of diseased tissue. We demonstrate magnetophoretic control of the nanoformulations in vitro wherein an external field is used to accelerate uptake and aggregate the nanoplatforms in cancer cells. Following uptake, the nanoplatforms are illuminated with the femtosecond-pulsed IR laser, which causes photothermal destruction of the cells due to plasmonically-enhanced heating and bubble generation. We show that field-induced aggregation dramatically enhances the ability to selectively destroy targeted cells compared to the same therapy in the absence of a field. We also demonstrate that magnetically aggregated nanoplatforms produce enhanced photoacoustic tomography (PAT).
Original languageEnglish
Title of host publicationTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Pages32-35
Number of pages4
Publication statusPublished - 20 Aug 2012
Externally publishedYes
EventNanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 - Santa Clara, CA, United States
Duration: 18 Jun 201221 Jun 2012

Conference

ConferenceNanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
CountryUnited States
CitySanta Clara, CA
Period18/06/1221/06/12

Keywords

  • LSPR-induced absorption
  • Magnetoplasmonic nanoplatform
  • Photoacoustic tomography
  • Photothermal cancer therapy
  • Plasmonic enhanced bubble nucleation

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces, Coatings and Films

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