Magnetic force microscopy of iron oxide nanoparticles and their cellular uptake

Yu Zhang, Mo Yang, Mihrimah Ozkan, Cengiz S. Ozkan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

18 Citations (Scopus)

Abstract

Magnetic force microscopy has the capability to detect magnetic domains from a close distance, which can provide the magnetic force gradient image of the scanned samples and also simultaneously obtain atomic force microscope (AFM) topography image as well as AFM phase image. In this work, we demonstrate the use of magnetic force microscopy together with AFM topography and phase imaging for the characterization of magnetic iron oxide nanoparticles and their cellular uptake behavior with the MCF7 carcinoma breast epithelial cells. This method can provide useful information such as the magnetic responses of nanoparticles, nanoparticle spatial localization, cell morphology, and cell surface domains at the same time for better understanding magnetic nanoparticle-cell interaction. It would help to design magnetic-related new imaging, diagnostic and therapeutic methods.
Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalBiotechnology Progress
Volume25
Issue number4
DOIs
Publication statusPublished - 1 Jul 2009

Keywords

  • Cancer cell
  • Cell culture
  • Iron oxide nanoparticle
  • Magnetic force microscopy
  • MCF7

ASJC Scopus subject areas

  • Biotechnology

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