Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells

Hua Wang, Wui Man Lau, Ning Li Wang, Si Ying Wang, Qing Jun Lu, Raymond Chuen Chung Chang, Kwok Fai So

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Lycium barbarum is a widely used Chinese herbal medicine prescription for protection of optic nerve. However, it remains unclear regarding the effects of Lycium barbarum polysaccharides, the main component of Lycium barbarum, on in vivo proliferation of adult ciliary body cells. In this study, adult rats were intragastrically administered low- and high-dose Lycium barbarum polysaccharides (1 and 10 mg/kg) for 35 days and those intragastrically administered phosphate buffered saline served as controls. The number of Ki-67-positive cells in rat ciliary body in the Lycium barbarum polysaccharides groups, in particular low-dose Lycium barbarum polysaccharides group, was significantly greater than that in the phosphate buffered saline group. Ki-67-positive rat ciliary body cells expressed nestin but they did not express glial fibrillary acidic protein. These findings suggest that Lycium barbarum polysaccharides can promote the proliferation of adult rat retinal progenitor cells and the proliferated cells present with neuronal phenotype.
Original languageEnglish
Pages (from-to)1976-1981
Number of pages6
JournalNeural Regeneration Research
Volume10
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • Adult
  • Lycium barbarum (wolfberry)
  • Lycium barbarum polysaccharides
  • Nerve regeneration
  • Neural regeneration
  • Neurogenesis
  • Retinal disease
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Developmental Neuroscience

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