Luminescent lanthanide metal-organic framework test strip for immediate detection of tetracycline antibiotics in water

Chongliang Li, Chenghui Zeng, Zhao Chen, Yefei Jiang, Hua Yao, Yangyi Yang, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

160 Citations (Scopus)


Tetracycline antibiotics (TCs) are a kind of commonly used antibiotics for treating infections, however, the overuse of TCs has adversely affected human health and the ecosystem. Thus, detection of TCs in water is important but challenging. In this work, a luminescent lanthanide metal-organic framework (LnMOF) sensor (1) for immediate detection of oxytetracycline (OTC) and tetracycline (TC) is developed. The sensor has high acid-base and water stability. Investigation reveals that among the 27 species of antibiotics, anions and cations under investigation, 1 shows highly selective sensing towards OTC and TC, and the detection is not disturbed by the presence of other species. The limit of detection (LOD) for OTC and TC are ultra-sensitive value of 1.95 and 2.77 nM, respectively. Investigation reveals the sensing mechanism is due to the inner filter effect. Further studies reveal that the sensor can be used in real sample monitoring. More importantly, test strips based on 1 are manufactured. They are an easy-to-use, low-cost, highly selective and sensitive sensing device for detecting OTC and TC. The sensing can be distinguished immediately and easily by the naked eyes, making it an excellent candidate to monitor OTC and TC in real use.

Original languageEnglish
Article number121498
JournalJournal of Hazardous Materials
Publication statusPublished - 15 Feb 2020


  • Immediate detection
  • Lanthanide metal-organic framework (LnMOF)
  • Sensor
  • Test strip
  • Tetracycline antibiotics (TCs)

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis


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