LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity

Keyphrases

• Locomotor 100%
• Inactivity 100%
• Reserpine 100%
• R1441C 100%
• Leucine-rich Repeat Kinase 2 (LRRK2) 100%
• Dopamine Depletion 100%
• Locomotor Activity 80%
• Idiopathic Parkinson's Disease 60%
• Nigrostriatal System 60%
• Dopamine Uptake 60%
• Midbrain 40%
• Vulnerability 40%
• Mutant Mice 40%
• Synaptic 40%
• Striatal 40%
• Knock-in mutation 40%
• Dopamine Homeostasis 40%
• Parkinson's Disease 20%
• Striatum 20%
• Cell Lysate 20%
• Immunostaining 20%
• Genetic Risk 20%
• C57BL 20%
• Ubiquitin 20%
• Striatal Dopamine 20%
• Tyrosine Hydroxylase 20%
• Nigrostriatal Dopamine 20%
• Slow Recovery 20%
• Uptake Behavior 20%
• Beclin-1 20%
• Early Change 20%
• Synaptic Proteins 20%
• Pathogenic Process 20%
• Alpha-synuclein (α-syn) 20%
• Neurite 20%
• Synaptic Dysfunction 20%
• Synaptic Vesicle Recycling 20%
• Tau Protein 20%
• Whole Brain 20%
• VMAT2 20%
• LC3B 20%
• Synaptosomes 20%
• Uptake Transporter 20%
• COXIV 20%
• Abnormal Phenotype 20%
• Nerve Terminal 20%
• GTPase Domain 20%
• Pathogenic Effects 20%
• Dopamine Neurons 20%
• Locomotor Deficits 20%
• Terminal Activity 20%

Neuroscience

• Reserpine 100%
• Leucine Rich Repeat Kinase 2 100%
• Locomotor Activity 80%
• Dopamine Uptake 60%
• Parkinson's Disease 40%
• Midbrain 40%
• Tyrosine Hydroxylase 20%
• Synuclein 20%
• Striatum 20%
• Ubiquitin 20%
• Synaptic Vesicle Recycling 20%
• Tau Protein 20%
• GTPase 20%
• Familial Parkinson's Disease 20%
• Beclin 1 20%
• Immunohistochemistry 20%
• Neurite 20%
• Vesicular Monoamine Transporter 2 20%
• Synaptosome 20%