Lower-limb neuroprostheses: Restoring walking after spinal cord injury

Regaining lower-limb functionality such as walking is one of the highest priorities among all the disabilities of paraplegics following Spinal Cord Injury (SCI). Though the ultimate recovery would be repairing or regenerating new axons across the spinal lesion (potentially by stem cells or other transplants and neurotropic factors), challenges to achieve this as well as recent technological advancements demand the development of new neuroprosthetic devices to restore such motor functions following the injuries. In this chapter, the authors discuss available therapies for the rehabilitation of SCI paraplegics and some new potential interventions that still require clinical tests. They also propose brain-machine-spinal cord interface as a future neuroprosthesis following motor complete SCI.