Lower degree of mineralization found in cortical bone of adolescent idiopathic

H.Y. Yeung, L. Qin, V.W. Hung, K.M. Lee, Xia Guo, B.W.K. Ng, J.C.Y. Cheng

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


A lowered bone mineral density (BMD) was observed in trabecular bone in a significant number of AIS patients. The present study aims at investigating whether lower BMD is a systemic phenomenon, which would also be present in the cortical component of long bone. Subjects and Methods. 78 AIS girls (age:15-18y.o) with either moderate (Cobb: 20–40) or severe (Cobb: >40) curve and 44 age-matched controls were recruited. The BMD of the distal region and the mid-shaft of radius were measured with a multi-layer peripheral quantitative computed tomography (pQCT). The trabecular bone and cortical bone BMD and the morphology of mid-shaft were compared. Results. Both trabecular and cortical BMD in severe AIS group was significantly lower than the control by 8.7% and 1.7% (p<0.05 for both), respectively. However, the cortical bone area of the mid-shaft did not show any differences from the normal control subjects. Discussion. This study demonstrates a systemic low BMD including the cortical bone. It is suggested that AIS girls may have disturbance in mineralization and ossification during peripubertal growth.
Original languageEnglish
Title of host publicationStudies in health technology and informatics
PublisherIOS Press
Number of pages6
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management


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