Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review

Poornima Palanisamy, Monzurul Alam, Shuai Li, Simon K.H. Chow, Yong Ping Zheng

Research output: Journal article publicationReview articleAcademic researchpeer-review

6 Citations (Scopus)


Low-intensity pulsed ultrasound (LIPUS) is a developing technology, which has been proven to improve fracture healing process with minimal thermal effects. This noninvasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cells. Although LIPUS treatment has shown beneficial effects on different bone fracture locations, only very few studies have examined its effects on deeper bones. This study provides an overview on therapeutic ultrasound for fractured bones, possible mechanisms of action, clinical evidences, current limitations, and its future prospects.

Original languageEnglish
Pages (from-to)547-563
Number of pages17
JournalJournal of Ultrasound in Medicine
Issue number3
Publication statusPublished - Mar 2022


  • bone healing
  • delayed unions
  • fresh fractures
  • low-intensity pulsed ultrasound
  • nonunions
  • ultrasound therapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review'. Together they form a unique fingerprint.

Cite this