Low-intensity pulsed ultrasound accelerates osteogenesis at bone-tendon healing junction

Ling Qin, Hongbin Lu, Pikkwan Fok, Winghoi Cheung, Yongping Zheng, Kwongman Lee, Kwoksui Leung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

57 Citations (Scopus)


This study was designed to evaluate low-intensity pulsed ultrasound (LIPUS) in acceleration of mineralization and remodeling of the new bone formed at the healing interface of bone-tendon junction. Thirty-two mature New Zealand white rabbits underwent partial patellectomy and direct repair of the patellar tendon and proximal patella. Animals were then divided into LIPUS treatment group (20 min/d, 5 times/wk) and placebo control group and were euthanized at week 8 and 16 postoperatively (n = 8, for each group and time point). The main outcome measures included new bone size and its bone mineral density (BMD). Results showed that the size of new bone was found to be 2.6 and 3.0 times significantly greater in the LIPUS group compared with that of the control group at weeks 8 and 16, respectively. In addition, the LIPUS group showed significantly higher BMD at week 8 than controls, but not at week 16. In conclusion, this was the first experimental study to show that LIPUS was able to enhance osteogenesis at the healing bone-tendon junction, especially before the postoperative week 8. Findings of this study formed a scientific basis for future clinical trials and establishment of indication of LIPUS for enhancing bone-tendon junction repair. (E-mail: Lingqin@cuhk.edu.hk).
Original languageEnglish
Pages (from-to)1905-1911
Number of pages7
JournalUltrasound in Medicine and Biology
Issue number12
Publication statusPublished - 1 Dec 2006


  • Bone mineral density
  • Bone remodeling
  • Bone-tendon junction repair
  • Histology
  • Low-intensity pulsed ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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