TY - JOUR
T1 - Longitudinal to Transverse Metachronal Wave Transitions in an in Vitro Model of Ciliated Bronchial Epithelium
AU - Mesdjian, Olivier
AU - Wang, Chenglei
AU - Gsell, Simon
AU - D'Ortona, Umberto
AU - Favier, Julien
AU - Viallat, Annie
AU - Loiseau, Etienne
N1 - Funding Information:
We thank Dr. K. Khelloufi for providing a movie. The project leading to this publication has received funding from the “Investissements d’Avenir” French government program managed by the French National Research Agency (No. ANR-16-CONV-0001) and from the Excellence Initiative of Aix-Marseille University—A*MIDEX. The Centre de Calcul Intensif d’Aix-Marseille University is acknowledged for granting access to its high-performance computing resources.
Publisher Copyright:
© 2022 American Physical Society.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - Myriads of cilia beat on ciliated epithelia, which are ubiquitous in life. When ciliary beats are synchronized, metachronal waves emerge, whose direction of propagation depends on the living system in an unexplained way. We show on a reconstructed human bronchial epithelium in vitro that the direction of propagation is determined by the ability of mucus to be transported at the epithelial surface. Numerical simulations show that longitudinal waves maximize the transport of mucus while transverse waves, observed when the mucus is rigid and still, minimize the energy dissipated by the cilia.
AB - Myriads of cilia beat on ciliated epithelia, which are ubiquitous in life. When ciliary beats are synchronized, metachronal waves emerge, whose direction of propagation depends on the living system in an unexplained way. We show on a reconstructed human bronchial epithelium in vitro that the direction of propagation is determined by the ability of mucus to be transported at the epithelial surface. Numerical simulations show that longitudinal waves maximize the transport of mucus while transverse waves, observed when the mucus is rigid and still, minimize the energy dissipated by the cilia.
UR - https://www.scopus.com/pages/publications/85134513724
U2 - 10.1103/PhysRevLett.129.038101
DO - 10.1103/PhysRevLett.129.038101
M3 - Journal article
AN - SCOPUS:85134513724
SN - 0031-9007
VL - 129
JO - Physical Review Letters
JF - Physical Review Letters
IS - 3
M1 - 038101
ER -