Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism

Zhixiong Lin; Linxing Chen; Yusen Fang; Aiqun Cai; Tuodan Zhang; Wing Cheung Vincent Wu

doi:10.1002/hed.23285

Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism

Zhixiong Lin, Linxing Chen, Yusen Fang, Aiqun Cai, Tuodan Zhang, Wing Cheung Vincent Wu

Research output: Journal article publication › Journal article › Academic research › peer-review

22 Citations (Scopus)

Abstract

Background The purpose of this study was to evaluate the correlations of thyroid antibody and thyroid hormone in postradiotherapy (post-RT) patients with nasopharyngeal carcinoma (NPC). Methods Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroperoxidase antibody (anti-TPO), and thyroglobulin antibody (anti-TG) levels of 55 patients with NPC were taken before RT and at 3, 6, 12, and 18 months after RT. Patients with hypothyroidism at 18 months after RT and those with normal thyroid function were categorized into the hypo and normal groups, respectively. The thyroid antibody levels were compared between the 2 groups, and the correlations of thyroid antibody and thyroid hormone were evaluated for the hypo group. Results The anti-TPO and anti-TG of the hypo group were higher than the normal group. In the hypo group, there was a positive correlation (r = 0.51) between TSH and anti-TG and a negative correlation between fT4 and anti-TPO (r = -0.55). Conclusion There were correlations of the thyroid antibody and thyroid hormone levels in patients with radiation-induced hypothyroidism.

Original language	English
Pages (from-to)	171-175
Number of pages	5
Journal	Head and Neck
Volume	36
Issue number	2
DOIs	https://doi.org/10.1002/hed.23285
Publication status	Published - 1 Feb 2014

Keywords

nasopharyngeal carcinoma
postradiotherapy
radiation-induced hypothyroidism
thyroid antibodies
thyroid hormones

ASJC Scopus subject areas

Otorhinolaryngology

More information

10.1002/hed.23285

Cite this

@article{332ce07156364351bde5e210d119a62f,

title = "Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism",

abstract = "Background The purpose of this study was to evaluate the correlations of thyroid antibody and thyroid hormone in postradiotherapy (post-RT) patients with nasopharyngeal carcinoma (NPC). Methods Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroperoxidase antibody (anti-TPO), and thyroglobulin antibody (anti-TG) levels of 55 patients with NPC were taken before RT and at 3, 6, 12, and 18 months after RT. Patients with hypothyroidism at 18 months after RT and those with normal thyroid function were categorized into the hypo and normal groups, respectively. The thyroid antibody levels were compared between the 2 groups, and the correlations of thyroid antibody and thyroid hormone were evaluated for the hypo group. Results The anti-TPO and anti-TG of the hypo group were higher than the normal group. In the hypo group, there was a positive correlation (r = 0.51) between TSH and anti-TG and a negative correlation between fT4 and anti-TPO (r = -0.55). Conclusion There were correlations of the thyroid antibody and thyroid hormone levels in patients with radiation-induced hypothyroidism.",

keywords = "nasopharyngeal carcinoma, postradiotherapy, radiation-induced hypothyroidism, thyroid antibodies, thyroid hormones",

author = "Zhixiong Lin and Linxing Chen and Yusen Fang and Aiqun Cai and Tuodan Zhang and Wu, {Wing Cheung Vincent}",

year = "2014",

month = feb,

day = "1",

doi = "10.1002/hed.23285",

language = "English",

volume = "36",

pages = "171--175",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism. / Lin, Zhixiong; Chen, Linxing; Fang, Yusen et al.
In: Head and Neck, Vol. 36, No. 2, 01.02.2014, p. 171-175.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism

AU - Lin, Zhixiong

AU - Chen, Linxing

AU - Fang, Yusen

AU - Cai, Aiqun

AU - Zhang, Tuodan

AU - Wu, Wing Cheung Vincent

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background The purpose of this study was to evaluate the correlations of thyroid antibody and thyroid hormone in postradiotherapy (post-RT) patients with nasopharyngeal carcinoma (NPC). Methods Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroperoxidase antibody (anti-TPO), and thyroglobulin antibody (anti-TG) levels of 55 patients with NPC were taken before RT and at 3, 6, 12, and 18 months after RT. Patients with hypothyroidism at 18 months after RT and those with normal thyroid function were categorized into the hypo and normal groups, respectively. The thyroid antibody levels were compared between the 2 groups, and the correlations of thyroid antibody and thyroid hormone were evaluated for the hypo group. Results The anti-TPO and anti-TG of the hypo group were higher than the normal group. In the hypo group, there was a positive correlation (r = 0.51) between TSH and anti-TG and a negative correlation between fT4 and anti-TPO (r = -0.55). Conclusion There were correlations of the thyroid antibody and thyroid hormone levels in patients with radiation-induced hypothyroidism.

AB - Background The purpose of this study was to evaluate the correlations of thyroid antibody and thyroid hormone in postradiotherapy (post-RT) patients with nasopharyngeal carcinoma (NPC). Methods Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroperoxidase antibody (anti-TPO), and thyroglobulin antibody (anti-TG) levels of 55 patients with NPC were taken before RT and at 3, 6, 12, and 18 months after RT. Patients with hypothyroidism at 18 months after RT and those with normal thyroid function were categorized into the hypo and normal groups, respectively. The thyroid antibody levels were compared between the 2 groups, and the correlations of thyroid antibody and thyroid hormone were evaluated for the hypo group. Results The anti-TPO and anti-TG of the hypo group were higher than the normal group. In the hypo group, there was a positive correlation (r = 0.51) between TSH and anti-TG and a negative correlation between fT4 and anti-TPO (r = -0.55). Conclusion There were correlations of the thyroid antibody and thyroid hormone levels in patients with radiation-induced hypothyroidism.

KW - nasopharyngeal carcinoma

KW - postradiotherapy

KW - radiation-induced hypothyroidism

KW - thyroid antibodies

KW - thyroid hormones

UR - http://www.scopus.com/inward/record.url?scp=84892446484&partnerID=8YFLogxK

U2 - 10.1002/hed.23285

DO - 10.1002/hed.23285

M3 - Journal article

C2 - 23559564

SN - 1043-3074

VL - 36

SP - 171

EP - 175

JO - Head and Neck

JF - Head and Neck

IS - 2

ER -

Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this