Long-Term Detection of Oncogenic MicroRNA in Living Human Cancer Cells by Gold@ Polydopamine–Shell Nanoprobe

Wai Ki Ricky Wong, Siu Hong Wong, Liming Bian

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Oncogenic microRNAs (miRNA), for example, miR-155, are key tumor biomarkers in cancer cells that drive tumorigenesis, and the miRNA profile signature can predict cancer development and aggressiveness. Hence, timely detection of oncogenic miRNA in living cells is highly attractive to the diagnosis of cancer at an early stage. Herein, we report a highly sequence-specific gold@polydopamine-based nanoprobe for long-term detection of miRNA in human cancer cell lines in vitro. A single administration of the nanoprobe enables continuous detection of the miR-155 expression level in living cancer cells for up to 5 days. We believe that our nanoprobe is highly promising for both oncology research and translational applications.
Original languageEnglish
Article number6
Pages (from-to)3778-3783
Number of pages6
JournalACS Biomaterials Science and Engineering
Volume6
Issue number7
Publication statusPublished - 13 Jul 2020

Keywords

  • cancer cellular uptake
  • fluorescence quenching
  • gold nanoprobes
  • long-term real-time imaging
  • oncogenic miRNA

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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