Long non-coding RNAs in obesity-induced cancer

Mabel Yin Chun Yau, Lu Xu, Chien Ling Huang, Chi Ming Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity.

Original languageEnglish
Article number19
JournalNon-coding RNA
Volume4
Issue number3
DOIs
Publication statusPublished - 28 Aug 2018

Keywords

  • ANRIL
  • Cancer
  • H19
  • HOTAIR
  • LncRNA
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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